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• W2078989982 abstract "Many different HIV-1 vaccine strategies have been developed, but as yet none has been completely successful. Promising results from combined DNA prime/protein boost vaccines have been reported. Specific immune responses generated by DNA vaccines can be modulated by the co-delivery of genes coding for cytokines. In this study, we have used the intradermal route by needle injection of a plasmid coding for the HIV-1 Nef accessory protein. We show that DNA prime/protein boost vaccine combinations increase the humoral and cellular immune responses against HIV-1 Nef and that the co-injection of DNA encoding Interleukin-18 (IL-18) modulates the specific immune response towards a Th1 type." @default.
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• W2078989982 date "2000-08-01" @default.
• W2078989982 modified "2023-09-23" @default.
• W2078989982 title "Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein boost vaccine" @default.
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• W2078989982 doi "https://doi.org/10.1016/s0264-410x(00)00157-2" @default.
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