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- W2078991803 abstract "The modification of neuronal connections in response to stimuli is believed to be the basis of long-term memory formation. It is currently accepted that local protein synthesis critically contributes to site-restricted modulation of individual synapses. Here, we summarize recent evidence implicating miRNAs in this process, leading to altered dendrite morphogenesis and synaptic plasticity. Second, we discuss findings in non-neuronal systems about how RNA-binding proteins can modulate miRNA–mRNA interactions, and how these mechanisms might apply to neurons. Finally, we review recent findings that P-bodies may be important sites for miRNA action at the synapse." @default.
- W2078991803 created "2016-06-24" @default.
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- W2078991803 date "2009-12-01" @default.
- W2078991803 modified "2023-09-25" @default.
- W2078991803 title "What are the roles of microRNAs at the mammalian synapse?" @default.
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- W2078991803 doi "https://doi.org/10.1016/j.neulet.2009.06.050" @default.
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