Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078993039> ?p ?o ?g. }
- W2078993039 endingPage "270" @default.
- W2078993039 startingPage "255" @default.
- W2078993039 abstract "A decline in the induction of heat shock protein 70 (hsp70) expression with age has been shown to occur in a variety of tissues from male rodents. Because the age-related change in the expression of many genes often differ in male and female rodents, we have measured the induction of hsp70 expression in hepatocytes and splenocytes from young/adult (4–8 months) and old (20–22 months) female Fischer 344 rats. Hepatocytes and splenocytes isolated from old female rats showed a marked decrease in the induction of hsp70 mRNA and protein levels by heat shock when compared to hepatocytes and splenocytes isolated from young/adult female rats. Because the heat shock transcription factor HSF1 mediates the heat-induced transcription of hsp70, the effect of age on HSF1 was also studied. The ability of extracts from heat-shocked splenocytes to bind to the heat shock element (HSE) decreased with age. Interestingly, the levels of HSF1 protein were similar in splenocytes and hepatocytes from old female rats compared to young/adult female rats, even though the levels of HSE-binding were lower for splenocytes isolated from old rats. In this study, we show an age-related decline in the expression of hsp70, and this decline was similar to what we had previously observed in male Fischer 344 rats." @default.
- W2078993039 created "2016-06-24" @default.
- W2078993039 creator A5007364549 @default.
- W2078993039 creator A5039978851 @default.
- W2078993039 creator A5061020688 @default.
- W2078993039 creator A5065795438 @default.
- W2078993039 date "1999-03-01" @default.
- W2078993039 modified "2023-10-15" @default.
- W2078993039 title "Expression of heat shock protein 70 decreases with age in hepatocytes and splenocytes from female rats" @default.
- W2078993039 cites W1506810006 @default.
- W2078993039 cites W1516501648 @default.
- W2078993039 cites W1971819783 @default.
- W2078993039 cites W1972458635 @default.
- W2078993039 cites W1974878663 @default.
- W2078993039 cites W1985606010 @default.
- W2078993039 cites W1992021393 @default.
- W2078993039 cites W2003088600 @default.
- W2078993039 cites W2005289306 @default.
- W2078993039 cites W2006609702 @default.
- W2078993039 cites W2007134868 @default.
- W2078993039 cites W2009968835 @default.
- W2078993039 cites W2013683245 @default.
- W2078993039 cites W2015599928 @default.
- W2078993039 cites W2024414544 @default.
- W2078993039 cites W2029739901 @default.
- W2078993039 cites W2030456774 @default.
- W2078993039 cites W2045856582 @default.
- W2078993039 cites W2060071007 @default.
- W2078993039 cites W2071748071 @default.
- W2078993039 cites W2079916236 @default.
- W2078993039 cites W2086016294 @default.
- W2078993039 cites W2087973596 @default.
- W2078993039 cites W2089748605 @default.
- W2078993039 cites W2094199438 @default.
- W2078993039 cites W2101911420 @default.
- W2078993039 cites W2137417707 @default.
- W2078993039 cites W2154616390 @default.
- W2078993039 cites W2165113979 @default.
- W2078993039 cites W2335541864 @default.
- W2078993039 cites W2414331982 @default.
- W2078993039 cites W254614570 @default.
- W2078993039 cites W4235592770 @default.
- W2078993039 cites W4246207627 @default.
- W2078993039 cites W4294216491 @default.
- W2078993039 doi "https://doi.org/10.1016/s0047-6374(98)00132-8" @default.
- W2078993039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10360681" @default.
- W2078993039 hasPublicationYear "1999" @default.
- W2078993039 type Work @default.
- W2078993039 sameAs 2078993039 @default.
- W2078993039 citedByCount "34" @default.
- W2078993039 countsByYear W20789930392012 @default.
- W2078993039 countsByYear W20789930392013 @default.
- W2078993039 countsByYear W20789930392014 @default.
- W2078993039 countsByYear W20789930392015 @default.
- W2078993039 countsByYear W20789930392016 @default.
- W2078993039 countsByYear W20789930392022 @default.
- W2078993039 countsByYear W20789930392023 @default.
- W2078993039 crossrefType "journal-article" @default.
- W2078993039 hasAuthorship W2078993039A5007364549 @default.
- W2078993039 hasAuthorship W2078993039A5039978851 @default.
- W2078993039 hasAuthorship W2078993039A5061020688 @default.
- W2078993039 hasAuthorship W2078993039A5065795438 @default.
- W2078993039 hasConcept C104317684 @default.
- W2078993039 hasConcept C105580179 @default.
- W2078993039 hasConcept C126322002 @default.
- W2078993039 hasConcept C134018914 @default.
- W2078993039 hasConcept C16685009 @default.
- W2078993039 hasConcept C189976730 @default.
- W2078993039 hasConcept C202751555 @default.
- W2078993039 hasConcept C203014093 @default.
- W2078993039 hasConcept C205260736 @default.
- W2078993039 hasConcept C2776200302 @default.
- W2078993039 hasConcept C2776667301 @default.
- W2078993039 hasConcept C52981337 @default.
- W2078993039 hasConcept C55493867 @default.
- W2078993039 hasConcept C68991219 @default.
- W2078993039 hasConcept C71924100 @default.
- W2078993039 hasConcept C86803240 @default.
- W2078993039 hasConcept C8891405 @default.
- W2078993039 hasConceptScore W2078993039C104317684 @default.
- W2078993039 hasConceptScore W2078993039C105580179 @default.
- W2078993039 hasConceptScore W2078993039C126322002 @default.
- W2078993039 hasConceptScore W2078993039C134018914 @default.
- W2078993039 hasConceptScore W2078993039C16685009 @default.
- W2078993039 hasConceptScore W2078993039C189976730 @default.
- W2078993039 hasConceptScore W2078993039C202751555 @default.
- W2078993039 hasConceptScore W2078993039C203014093 @default.
- W2078993039 hasConceptScore W2078993039C205260736 @default.
- W2078993039 hasConceptScore W2078993039C2776200302 @default.
- W2078993039 hasConceptScore W2078993039C2776667301 @default.
- W2078993039 hasConceptScore W2078993039C52981337 @default.
- W2078993039 hasConceptScore W2078993039C55493867 @default.
- W2078993039 hasConceptScore W2078993039C68991219 @default.
- W2078993039 hasConceptScore W2078993039C71924100 @default.
- W2078993039 hasConceptScore W2078993039C86803240 @default.
- W2078993039 hasConceptScore W2078993039C8891405 @default.
- W2078993039 hasIssue "3" @default.
- W2078993039 hasLocation W20789930391 @default.