Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078994313> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2078994313 endingPage "1361" @default.
- W2078994313 startingPage "1351" @default.
- W2078994313 abstract "The present study compared the behavioral and toxic effects of cocaine and its ethanol derived metabolite, cocaine ethyl-ester (cocaethylene). Both drugs produced qualitatively similar psychomotor stimulant effects. Cocaine and cocaethylene increased locomotor activity in mice, with cocaine approximately four times more potent than cocaethylene. The durations of action of ED75 doses of each of the drugs were comparable. Each of the drugs also produced stimulation of operant responding in rats. In rats and squirrel monkeys trained to discriminate cocaine injections from saline, cocaine was approximately three to five times more potent than cocaethylene in producing these cocaine-like interoceptive effects. In contrast to the behavioral effects, cocaine and cocaethylene were equipotent in producing convulsions, and cocaethylene was more potent than cocaine in producing lethality. These results suggest that the conversion of cocaine to cocaethylene with simultaneous cocaine and alcohol use may produce an increased risk of toxicity due to a decrease in the potency of cocaethylene in producing pschomotor stimulant effects, and its increased potency in producing toxicity." @default.
- W2078994313 created "2016-06-24" @default.
- W2078994313 creator A5042018278 @default.
- W2078994313 creator A5067751090 @default.
- W2078994313 creator A5090899159 @default.
- W2078994313 date "1992-01-01" @default.
- W2078994313 modified "2023-09-30" @default.
- W2078994313 title "Comparative behavioral pharmacology and toxicology of cocaine and its ethhanol-derived metabolite, cocaine ethyl-ester (cocaethylene)" @default.
- W2078994313 cites W1968217097 @default.
- W2078994313 cites W1974970522 @default.
- W2078994313 cites W1983518330 @default.
- W2078994313 cites W1988288620 @default.
- W2078994313 cites W2001858122 @default.
- W2078994313 cites W2039506066 @default.
- W2078994313 cites W2076019951 @default.
- W2078994313 cites W2076478001 @default.
- W2078994313 cites W2086636867 @default.
- W2078994313 cites W2096948351 @default.
- W2078994313 cites W2110172629 @default.
- W2078994313 cites W2111448535 @default.
- W2078994313 cites W2118668347 @default.
- W2078994313 cites W2123162695 @default.
- W2078994313 cites W2135015499 @default.
- W2078994313 cites W2156282359 @default.
- W2078994313 doi "https://doi.org/10.1016/0024-3205(92)90286-x" @default.
- W2078994313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1532847" @default.
- W2078994313 hasPublicationYear "1992" @default.
- W2078994313 type Work @default.
- W2078994313 sameAs 2078994313 @default.
- W2078994313 citedByCount "122" @default.
- W2078994313 countsByYear W20789943132012 @default.
- W2078994313 countsByYear W20789943132013 @default.
- W2078994313 countsByYear W20789943132014 @default.
- W2078994313 countsByYear W20789943132015 @default.
- W2078994313 countsByYear W20789943132017 @default.
- W2078994313 countsByYear W20789943132018 @default.
- W2078994313 countsByYear W20789943132019 @default.
- W2078994313 countsByYear W20789943132022 @default.
- W2078994313 countsByYear W20789943132023 @default.
- W2078994313 crossrefType "journal-article" @default.
- W2078994313 hasAuthorship W2078994313A5042018278 @default.
- W2078994313 hasAuthorship W2078994313A5067751090 @default.
- W2078994313 hasAuthorship W2078994313A5090899159 @default.
- W2078994313 hasConcept C124315065 @default.
- W2078994313 hasConcept C178790620 @default.
- W2078994313 hasConcept C185592680 @default.
- W2078994313 hasConcept C202751555 @default.
- W2078994313 hasConcept C2777477808 @default.
- W2078994313 hasConcept C2780161600 @default.
- W2078994313 hasConcept C2780557958 @default.
- W2078994313 hasConcept C29730261 @default.
- W2078994313 hasConcept C55493867 @default.
- W2078994313 hasConcept C57992300 @default.
- W2078994313 hasConcept C71924100 @default.
- W2078994313 hasConcept C98274493 @default.
- W2078994313 hasConceptScore W2078994313C124315065 @default.
- W2078994313 hasConceptScore W2078994313C178790620 @default.
- W2078994313 hasConceptScore W2078994313C185592680 @default.
- W2078994313 hasConceptScore W2078994313C202751555 @default.
- W2078994313 hasConceptScore W2078994313C2777477808 @default.
- W2078994313 hasConceptScore W2078994313C2780161600 @default.
- W2078994313 hasConceptScore W2078994313C2780557958 @default.
- W2078994313 hasConceptScore W2078994313C29730261 @default.
- W2078994313 hasConceptScore W2078994313C55493867 @default.
- W2078994313 hasConceptScore W2078994313C57992300 @default.
- W2078994313 hasConceptScore W2078994313C71924100 @default.
- W2078994313 hasConceptScore W2078994313C98274493 @default.
- W2078994313 hasIssue "18" @default.
- W2078994313 hasLocation W20789943131 @default.
- W2078994313 hasLocation W20789943132 @default.
- W2078994313 hasOpenAccess W2078994313 @default.
- W2078994313 hasPrimaryLocation W20789943131 @default.
- W2078994313 hasRelatedWork W1970831995 @default.
- W2078994313 hasRelatedWork W1990128461 @default.
- W2078994313 hasRelatedWork W2023487034 @default.
- W2078994313 hasRelatedWork W2075012981 @default.
- W2078994313 hasRelatedWork W2078994313 @default.
- W2078994313 hasRelatedWork W2112727823 @default.
- W2078994313 hasRelatedWork W2188520041 @default.
- W2078994313 hasRelatedWork W2336887693 @default.
- W2078994313 hasRelatedWork W2886148610 @default.
- W2078994313 hasRelatedWork W2785926487 @default.
- W2078994313 hasVolume "50" @default.
- W2078994313 isParatext "false" @default.
- W2078994313 isRetracted "false" @default.
- W2078994313 magId "2078994313" @default.
- W2078994313 workType "article" @default.