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- W2078995022 abstract "No fully validated biological markers currently exist to predict responsiveness to or the development of evasion to anti-angiogenic therapy of cancer. The identification of such biomarkers is vital to move these therapies forward, as failure to respond to these treatments is often associated with rapid tumor progression that could have been averted had the intrinsic or acquired evasion to anti-angiogenic therapy been identified in a timely fashion. Furthermore, the high cost of antiangiogenic therapies makes it important to avoid utilizing them in the setting of lack of response or developing evasion, making the identification of biomarkers even more important. A number of potential physiologic, circulating, tissue, and imaging biomarkers have emerged from recently completed preclinical animal studies and clinical trials. In this review, we define 5 different types of biomarkers (physiologic, circulating, intratumoral, genetic polymorphisms, and radiographic); discuss the challenges in establishing biomarkers of antiangiogenic therapy in animal models and in clinical trials; and discuss future strategies to identify and validate biomarkers of anti-angiogenic therapy." @default.
- W2078995022 created "2016-06-24" @default.
- W2078995022 creator A5035762375 @default.
- W2078995022 creator A5049126969 @default.
- W2078995022 date "2012-01-01" @default.
- W2078995022 modified "2023-09-25" @default.
- W2078995022 title "Biomarkers predicting tumor response and evasion to anti-angiogenic therapy" @default.
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- W2078995022 doi "https://doi.org/10.1016/j.bbcan.2011.10.004" @default.
- W2078995022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22067555" @default.
- W2078995022 hasPublicationYear "2012" @default.
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