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- W2078995149 abstract "The interactions of taurine with GABAB receptors were studied in membranes from the brain of the mouse by measuring the binding of [3H]baclofen and that of [3H]GABA in the presence of isoguvacine. Taurine displaced ligand binding to GABAB receptors concentration-dependently with an IC50 in the micromolar range. The effects of baclofen on the release of taurine and GABA from slices of cerebral cortex of the mouse were assessed using a superfusion system. Potassium-stimulated release of both [3H]taurine and [3H]GABA was unaffected by baclofen but potentiated by δ-aminovalerate. The enhancement of release of [3H]taurine by δ-aminovalerate was partially antagonized by baclofen, suggesting that baclofen-sensitive receptors could modify the release." @default.
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- W2078995149 title "Interactions of taurine with GABAB binding sites in mouse brain" @default.
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- W2078995149 doi "https://doi.org/10.1016/0028-3908(90)90008-f" @default.
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