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- W2078996912 abstract "An abnormal release of excitatory amino acids (EAA) is involved in the generation and expression of some epileptic seizures. In a previous study [1], we showed that safranal, a constituent of Crocus sativus, has a protective effect against both, clonic and tonic phases of pentylenetetrazole (PTZ)-induced seizures in rats. In this study, the effect of safranal pretreatment on concomitant changes in the extracellular hippocampal levels of EAA (glutamate and aspartate) following systemic administration of kainic acid (KA) was investigated in anesthetized rats, using a microdialysis method combined with liquid chromatography (HPLC). Safranal (72.75mg/kg or 291mg/kg, ip) was injected 40min before KA (15mg/kg, ip). The basal hippocampal concentrations of glutamate and aspartate were estimated to be 0.45µM and 0.29µM, respectively. Basal EAA levels were not affected by pretreatment with safranal. Following KA injection, there was a significant increase (p<0.001, Tukey-Kramer test) in the extracellular glutamate and aspartate levels (about 5 times and 3 times, respectively) at 80min after injection. However, kainite-evoked release of EAA was significantly reduced by safranal (291mg/kg, ip; p<0.001). The results showed that acute systemic injection of safranal reduces the extracellular concentrations of glutamate and aspartate in the rat hippocampus during seizures induced by KA." @default.
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- W2078996912 modified "2023-09-25" @default.
- W2078996912 title "Effect of safranal from Crocus sativus on extracellular hippocampal levels of glutamate and aspartate during kainic acid seizures in anesthetized rats" @default.
- W2078996912 doi "https://doi.org/10.1055/s-2007-987240" @default.
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