Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078996971> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2078996971 endingPage "12305" @default.
- W2078996971 startingPage "12300" @default.
- W2078996971 abstract "The relationship between enzyme architecture and substrate specificity among archaeal pre-tRNA splicing endonucleases has been investigated more deeply, by using biochemical assays and model building. The enzyme from Archeoglobus fulgidus (AF) is particularly interesting: it cleaves the bulge–helix–bulge target without requiring the mature tRNA domain, but, when the target is a bulge–helix–loop, the mature domain is required. A model of AF based on its electrostatic potential shows three polar patches interacting with the pre-tRNA substrate. A simple deletion mutant of the AF endonuclease lacking two of the three polar patches no longer cleaves the bulge–helix–loop substrate with or without the mature domain. This single deletion shows a possible path for the evolution of eukaryal splicing endonucleases from the archaeal enzyme." @default.
- W2078996971 created "2016-06-24" @default.
- W2078996971 creator A5035571531 @default.
- W2078996971 creator A5082331645 @default.
- W2078996971 creator A5084362659 @default.
- W2078996971 date "2007-07-24" @default.
- W2078996971 modified "2023-09-25" @default.
- W2078996971 title "The dawn of dominance by the mature domain in tRNA splicing" @default.
- W2078996971 cites W1853491092 @default.
- W2078996971 cites W1861739715 @default.
- W2078996971 cites W1964218148 @default.
- W2078996971 cites W1968832089 @default.
- W2078996971 cites W1972931607 @default.
- W2078996971 cites W1993635206 @default.
- W2078996971 cites W1995006714 @default.
- W2078996971 cites W1997529651 @default.
- W2078996971 cites W1997690732 @default.
- W2078996971 cites W2001147604 @default.
- W2078996971 cites W2007597735 @default.
- W2078996971 cites W2029667189 @default.
- W2078996971 cites W2031989207 @default.
- W2078996971 cites W2040748123 @default.
- W2078996971 cites W2049951186 @default.
- W2078996971 cites W2051698639 @default.
- W2078996971 cites W2070611781 @default.
- W2078996971 cites W2074651346 @default.
- W2078996971 cites W2087294104 @default.
- W2078996971 cites W2092296568 @default.
- W2078996971 cites W2101056544 @default.
- W2078996971 cites W2134505572 @default.
- W2078996971 cites W2150785142 @default.
- W2078996971 cites W4246174145 @default.
- W2078996971 cites W953973659 @default.
- W2078996971 doi "https://doi.org/10.1073/pnas.0705537104" @default.
- W2078996971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1941465" @default.
- W2078996971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17636125" @default.
- W2078996971 hasPublicationYear "2007" @default.
- W2078996971 type Work @default.
- W2078996971 sameAs 2078996971 @default.
- W2078996971 citedByCount "11" @default.
- W2078996971 countsByYear W20789969712012 @default.
- W2078996971 countsByYear W20789969712014 @default.
- W2078996971 countsByYear W20789969712015 @default.
- W2078996971 countsByYear W20789969712023 @default.
- W2078996971 crossrefType "journal-article" @default.
- W2078996971 hasAuthorship W2078996971A5035571531 @default.
- W2078996971 hasAuthorship W2078996971A5082331645 @default.
- W2078996971 hasAuthorship W2078996971A5084362659 @default.
- W2078996971 hasBestOaLocation W20789969711 @default.
- W2078996971 hasConcept C104317684 @default.
- W2078996971 hasConcept C153957851 @default.
- W2078996971 hasConcept C181199279 @default.
- W2078996971 hasConcept C2777028655 @default.
- W2078996971 hasConcept C54355233 @default.
- W2078996971 hasConcept C54458228 @default.
- W2078996971 hasConcept C55493867 @default.
- W2078996971 hasConcept C67705224 @default.
- W2078996971 hasConcept C86803240 @default.
- W2078996971 hasConceptScore W2078996971C104317684 @default.
- W2078996971 hasConceptScore W2078996971C153957851 @default.
- W2078996971 hasConceptScore W2078996971C181199279 @default.
- W2078996971 hasConceptScore W2078996971C2777028655 @default.
- W2078996971 hasConceptScore W2078996971C54355233 @default.
- W2078996971 hasConceptScore W2078996971C54458228 @default.
- W2078996971 hasConceptScore W2078996971C55493867 @default.
- W2078996971 hasConceptScore W2078996971C67705224 @default.
- W2078996971 hasConceptScore W2078996971C86803240 @default.
- W2078996971 hasIssue "30" @default.
- W2078996971 hasLocation W20789969711 @default.
- W2078996971 hasLocation W20789969712 @default.
- W2078996971 hasLocation W20789969713 @default.
- W2078996971 hasLocation W20789969714 @default.
- W2078996971 hasOpenAccess W2078996971 @default.
- W2078996971 hasPrimaryLocation W20789969711 @default.
- W2078996971 hasRelatedWork W1658899117 @default.
- W2078996971 hasRelatedWork W1997529651 @default.
- W2078996971 hasRelatedWork W2052418918 @default.
- W2078996971 hasRelatedWork W2378384290 @default.
- W2078996971 hasRelatedWork W3046777634 @default.
- W2078996971 hasRelatedWork W3202860293 @default.
- W2078996971 hasRelatedWork W40679281 @default.
- W2078996971 hasRelatedWork W4230992485 @default.
- W2078996971 hasRelatedWork W4241890154 @default.
- W2078996971 hasRelatedWork W4362664617 @default.
- W2078996971 hasVolume "104" @default.
- W2078996971 isParatext "false" @default.
- W2078996971 isRetracted "false" @default.
- W2078996971 magId "2078996971" @default.
- W2078996971 workType "article" @default.