FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078998991> ?p ?o ?g. }

• W2078998991 endingPage "89" @default.
• W2078998991 startingPage "82" @default.
• W2078998991 abstract "Previous studies have shown that multidrug resistance (MDR) in the doxorubicin-selected lung tumour cell lines COR-L23/R, GLC4/ADR and MOR/R is associated with overexpression of the MRP gene. In this study we report that resistance to daunorubicin, vincristine and rhodamine 123 can be partially reversed in these cell lines by exposing the cells to buthionine sulphoximine (BSO), an inhibitor of glutathione (GSH) synthesis. This effect of BSO on drug resistance was associated with an increased intracellular accumulation of daunorubicin and rhodamine 123, owing to inhibition of the enhanced drug efflux. In contrast, the accumulation of daunorubicin was not increased by BSO treatment in a P-glycoprotein (P-gp)-mediated MDR cell line. BSO treatment (25 microM, 20 h) of the cell lines resulted in 60-80% depletion of cellular GSH levels. The effects of BSO on daunorubicin accumulation in the COR-L23/R and GLC4/ADR cells were associated with cellular GSH depletion. In addition, increase of cellular GSH levels in BSO-treated COR-L23/R and GLC4/ADR cells as a result of incubation with 5 mM GSH ethyl ester restored the accumulation deficit of daunorubicin. However, the transport of daunorubicin did not increase the GSH release in any of the cell lines. These results demonstrate that drug transport in MRP- but not in P-gp-overexpressing MDR tumour cell lines can be regulated by intracellular GSH levels." @default.
• W2078998991 created "2016-06-24" @default.
• W2078998991 creator A5011171028 @default.
• W2078998991 creator A5030642912 @default.
• W2078998991 creator A5041659198 @default.
• W2078998991 creator A5074059270 @default.
• W2078998991 creator A5085426388 @default.
• W2078998991 date "1995-07-01" @default.
• W2078998991 modified "2023-10-15" @default.
• W2078998991 title "Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein" @default.
• W2078998991 cites W1514403557 @default.
• W2078998991 cites W1531372132 @default.
• W2078998991 cites W1532556593 @default.
• W2078998991 cites W1557087064 @default.
• W2078998991 cites W1595506167 @default.
• W2078998991 cites W1648335868 @default.
• W2078998991 cites W1815735775 @default.
• W2078998991 cites W1966255834 @default.
• W2078998991 cites W1984017142 @default.
• W2078998991 cites W1985032385 @default.
• W2078998991 cites W2012120642 @default.
• W2078998991 cites W2013541526 @default.
• W2078998991 cites W2041424676 @default.
• W2078998991 cites W2048105633 @default.
• W2078998991 cites W2063576996 @default.
• W2078998991 cites W2066805487 @default.
• W2078998991 cites W2067493329 @default.
• W2078998991 cites W2067898376 @default.
• W2078998991 cites W2068521859 @default.
• W2078998991 cites W2080442428 @default.
• W2078998991 cites W2080736726 @default.
• W2078998991 cites W2101278212 @default.
• W2078998991 cites W2118234018 @default.
• W2078998991 cites W2127819051 @default.
• W2078998991 cites W2130613069 @default.
• W2078998991 cites W2140934606 @default.
• W2078998991 cites W2143862282 @default.
• W2078998991 cites W2144312298 @default.
• W2078998991 cites W2152117655 @default.
• W2078998991 cites W2157876917 @default.
• W2078998991 cites W2164888491 @default.
• W2078998991 cites W2165096142 @default.
• W2078998991 cites W2168070336 @default.
• W2078998991 cites W2168095256 @default.
• W2078998991 cites W2172106270 @default.
• W2078998991 cites W2340961481 @default.
• W2078998991 cites W2400531137 @default.
• W2078998991 cites W2401284641 @default.
• W2078998991 doi "https://doi.org/10.1038/bjc.1995.281" @default.
• W2078998991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2034163" @default.
• W2078998991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7599070" @default.
• W2078998991 hasPublicationYear "1995" @default.
• W2078998991 type Work @default.
• W2078998991 sameAs 2078998991 @default.
• W2078998991 citedByCount "199" @default.
• W2078998991 countsByYear W20789989912012 @default.
• W2078998991 countsByYear W20789989912014 @default.
• W2078998991 countsByYear W20789989912015 @default.
• W2078998991 countsByYear W20789989912016 @default.
• W2078998991 countsByYear W20789989912017 @default.
• W2078998991 countsByYear W20789989912019 @default.
• W2078998991 countsByYear W20789989912020 @default.
• W2078998991 countsByYear W20789989912021 @default.
• W2078998991 countsByYear W20789989912022 @default.
• W2078998991 countsByYear W20789989912023 @default.
• W2078998991 crossrefType "journal-article" @default.
• W2078998991 hasAuthorship W2078998991A5011171028 @default.
• W2078998991 hasAuthorship W2078998991A5030642912 @default.
• W2078998991 hasAuthorship W2078998991A5041659198 @default.
• W2078998991 hasAuthorship W2078998991A5074059270 @default.
• W2078998991 hasAuthorship W2078998991A5085426388 @default.
• W2078998991 hasBestOaLocation W20789989911 @default.
• W2078998991 hasConcept C114851261 @default.
• W2078998991 hasConcept C133936738 @default.
• W2078998991 hasConcept C153911025 @default.
• W2078998991 hasConcept C181199279 @default.
• W2078998991 hasConcept C185592680 @default.
• W2078998991 hasConcept C200082930 @default.
• W2078998991 hasConcept C203014093 @default.
• W2078998991 hasConcept C2776694085 @default.
• W2078998991 hasConcept C2777476445 @default.
• W2078998991 hasConcept C2778461978 @default.
• W2078998991 hasConcept C2778589691 @default.
• W2078998991 hasConcept C2778707650 @default.
• W2078998991 hasConcept C2781021840 @default.
• W2078998991 hasConcept C2781303535 @default.
• W2078998991 hasConcept C538909803 @default.
• W2078998991 hasConcept C54355233 @default.
• W2078998991 hasConcept C55493867 @default.
• W2078998991 hasConcept C79879829 @default.
• W2078998991 hasConcept C81885089 @default.
• W2078998991 hasConcept C86803240 @default.
• W2078998991 hasConcept C89423630 @default.
• W2078998991 hasConcept C98274493 @default.
• W2078998991 hasConceptScore W2078998991C114851261 @default.
• W2078998991 hasConceptScore W2078998991C133936738 @default.
• W2078998991 hasConceptScore W2078998991C153911025 @default.
• W2078998991 hasConceptScore W2078998991C181199279 @default.

• next