Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079006707> ?p ?o ?g. }
- W2079006707 endingPage "581" @default.
- W2079006707 startingPage "572" @default.
- W2079006707 abstract "Abstract Wound healing disorders are a therapeutic problem of increasing clinical importance involving substantial morbidity, mortality, and rising health costs. Our studies investigating flightless I (FliI), a highly conserved actin‐remodelling protein, now reveal that FliI is an important regulator of wound repair whose manipulation may lead to enhanced wound outcomes. We demonstrate that FliI‐deficient + /− mice are characterized by improved wound healing with increased epithelial migration and enhanced wound contraction. In contrast, FliI‐overexpressing mice have significantly impaired wound healing with larger less contracted wounds and reduced cellular proliferation. We show that FliI is secreted in response to wounding and that topical application of antibodies raised against the leucine‐rich repeat domain of the FliI protein (FliL) significantly improves wound repair. These studies reveal that FliI affects wound repair via mechanisms involving cell migration and proliferation and that FliI might represent an effective novel therapeutic factor to improve conditions in which wound healing is impaired. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
- W2079006707 created "2016-06-24" @default.
- W2079006707 creator A5014394237 @default.
- W2079006707 creator A5041803563 @default.
- W2079006707 creator A5043573274 @default.
- W2079006707 creator A5055932476 @default.
- W2079006707 creator A5056107858 @default.
- W2079006707 creator A5061304152 @default.
- W2079006707 creator A5063186115 @default.
- W2079006707 creator A5066363767 @default.
- W2079006707 creator A5069300860 @default.
- W2079006707 creator A5073674884 @default.
- W2079006707 date "2007-02-26" @default.
- W2079006707 modified "2023-10-14" @default.
- W2079006707 title "Flightless I deficiency enhances wound repair by increasing cell migration and proliferation" @default.
- W2079006707 cites W1493072136 @default.
- W2079006707 cites W1925705209 @default.
- W2079006707 cites W1931924547 @default.
- W2079006707 cites W1970651122 @default.
- W2079006707 cites W1976154823 @default.
- W2079006707 cites W1980295525 @default.
- W2079006707 cites W1981045929 @default.
- W2079006707 cites W1982021133 @default.
- W2079006707 cites W1986703217 @default.
- W2079006707 cites W1990995529 @default.
- W2079006707 cites W1994849711 @default.
- W2079006707 cites W2017946623 @default.
- W2079006707 cites W2020021476 @default.
- W2079006707 cites W2027113655 @default.
- W2079006707 cites W2036692173 @default.
- W2079006707 cites W2062877496 @default.
- W2079006707 cites W2069521331 @default.
- W2079006707 cites W2070665737 @default.
- W2079006707 cites W2082789082 @default.
- W2079006707 cites W2106110723 @default.
- W2079006707 cites W2122306770 @default.
- W2079006707 cites W2162049443 @default.
- W2079006707 doi "https://doi.org/10.1002/path.2143" @default.
- W2079006707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17326236" @default.
- W2079006707 hasPublicationYear "2007" @default.
- W2079006707 type Work @default.
- W2079006707 sameAs 2079006707 @default.
- W2079006707 citedByCount "89" @default.
- W2079006707 countsByYear W20790067072012 @default.
- W2079006707 countsByYear W20790067072013 @default.
- W2079006707 countsByYear W20790067072014 @default.
- W2079006707 countsByYear W20790067072015 @default.
- W2079006707 countsByYear W20790067072016 @default.
- W2079006707 countsByYear W20790067072017 @default.
- W2079006707 countsByYear W20790067072018 @default.
- W2079006707 countsByYear W20790067072019 @default.
- W2079006707 countsByYear W20790067072020 @default.
- W2079006707 countsByYear W20790067072021 @default.
- W2079006707 countsByYear W20790067072022 @default.
- W2079006707 countsByYear W20790067072023 @default.
- W2079006707 crossrefType "journal-article" @default.
- W2079006707 hasAuthorship W2079006707A5014394237 @default.
- W2079006707 hasAuthorship W2079006707A5041803563 @default.
- W2079006707 hasAuthorship W2079006707A5043573274 @default.
- W2079006707 hasAuthorship W2079006707A5055932476 @default.
- W2079006707 hasAuthorship W2079006707A5056107858 @default.
- W2079006707 hasAuthorship W2079006707A5061304152 @default.
- W2079006707 hasAuthorship W2079006707A5063186115 @default.
- W2079006707 hasAuthorship W2079006707A5066363767 @default.
- W2079006707 hasAuthorship W2079006707A5069300860 @default.
- W2079006707 hasAuthorship W2079006707A5073674884 @default.
- W2079006707 hasConcept C137738243 @default.
- W2079006707 hasConcept C1491633281 @default.
- W2079006707 hasConcept C203014093 @default.
- W2079006707 hasConcept C2780269544 @default.
- W2079006707 hasConcept C55493867 @default.
- W2079006707 hasConcept C62112901 @default.
- W2079006707 hasConcept C71924100 @default.
- W2079006707 hasConcept C86803240 @default.
- W2079006707 hasConcept C95444343 @default.
- W2079006707 hasConceptScore W2079006707C137738243 @default.
- W2079006707 hasConceptScore W2079006707C1491633281 @default.
- W2079006707 hasConceptScore W2079006707C203014093 @default.
- W2079006707 hasConceptScore W2079006707C2780269544 @default.
- W2079006707 hasConceptScore W2079006707C55493867 @default.
- W2079006707 hasConceptScore W2079006707C62112901 @default.
- W2079006707 hasConceptScore W2079006707C71924100 @default.
- W2079006707 hasConceptScore W2079006707C86803240 @default.
- W2079006707 hasConceptScore W2079006707C95444343 @default.
- W2079006707 hasIssue "5" @default.
- W2079006707 hasLocation W20790067071 @default.
- W2079006707 hasOpenAccess W2079006707 @default.
- W2079006707 hasPrimaryLocation W20790067071 @default.
- W2079006707 hasRelatedWork W2083693850 @default.
- W2079006707 hasRelatedWork W2201991444 @default.
- W2079006707 hasRelatedWork W2324018797 @default.
- W2079006707 hasRelatedWork W2365457660 @default.
- W2079006707 hasRelatedWork W2537202170 @default.
- W2079006707 hasRelatedWork W2575770495 @default.
- W2079006707 hasRelatedWork W2616477852 @default.
- W2079006707 hasRelatedWork W3203809849 @default.
- W2079006707 hasRelatedWork W4283809963 @default.
- W2079006707 hasRelatedWork W4323029873 @default.