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- W2079008385 abstract "Platelets from healthy females, who were taking oral contraceptives over a long period of time, were investigated by ultrastructural morphometry. The size, shape, relative volumes, numerical and surface densities of the platelets and their organelles were measured. In 'long-term pill users' the platelets showed a significant increase in the area of section profile. Further changes as, for example, increased volume of platelet granules, reduced number of mitochondria, decreased volume and surface of the open canalicular system, and increased surface of the dense tubular system are to be noted.Ultrastructural morphometry was used to measure the size, shape, relative volumes, and numerical and surface densities of platelets and their organelles from 10 longterm (up to 5 years) oral contraceptive (OC) users. Platelet materials from 14 non-OC users were also examined as a basis for comparison. The value for the area of section profile was 27% larger in OC users than in controls and the volume density of granules was 24% larger. The length of the platelet major axis, the axial ratio, and the boundary length of platelet profile did not differ significantly between the 2 groups. The surface density of granules was 2.743 mcgm2/mcgm3 in cases compared with 2.313 mcgm2/mcgm3 in controls. The numerical density of mitochondria was 46% smaller in OC users and the surface density of the dense tubular system was 97% larger. Overall, these finding suggest deviations in form and structure of platelets in OC users as well as an increase in platelet volume. It is recommended that morphology be correlated to an altered storage and transport function in platelet in OC users." @default.
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- W2079008385 date "1979-10-01" @default.
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- W2079008385 title "Ultrastructural morphometric investigations on human platelets after long-term ingestion of oral contraceptives" @default.
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- W2079008385 doi "https://doi.org/10.1016/0028-2243(79)90083-2" @default.
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