Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079009086> ?p ?o ?g. }
- W2079009086 endingPage "10" @default.
- W2079009086 startingPage "1" @default.
- W2079009086 abstract "Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food." @default.
- W2079009086 created "2016-06-24" @default.
- W2079009086 creator A5018285493 @default.
- W2079009086 creator A5084900431 @default.
- W2079009086 creator A5090507281 @default.
- W2079009086 date "2013-01-01" @default.
- W2079009086 modified "2023-10-16" @default.
- W2079009086 title "Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior" @default.
- W2079009086 cites W1481893565 @default.
- W2079009086 cites W1575624911 @default.
- W2079009086 cites W1579647545 @default.
- W2079009086 cites W1627229807 @default.
- W2079009086 cites W1793127045 @default.
- W2079009086 cites W1959892192 @default.
- W2079009086 cites W1965798314 @default.
- W2079009086 cites W1968788710 @default.
- W2079009086 cites W1968914473 @default.
- W2079009086 cites W1968973186 @default.
- W2079009086 cites W1972318216 @default.
- W2079009086 cites W1974909743 @default.
- W2079009086 cites W1974916475 @default.
- W2079009086 cites W1975684351 @default.
- W2079009086 cites W1975983146 @default.
- W2079009086 cites W1976051280 @default.
- W2079009086 cites W1976095017 @default.
- W2079009086 cites W1977858533 @default.
- W2079009086 cites W1978082185 @default.
- W2079009086 cites W1978377475 @default.
- W2079009086 cites W1979110766 @default.
- W2079009086 cites W1979616143 @default.
- W2079009086 cites W1980603718 @default.
- W2079009086 cites W1980872889 @default.
- W2079009086 cites W1981256051 @default.
- W2079009086 cites W1983298714 @default.
- W2079009086 cites W1983627599 @default.
- W2079009086 cites W1985664105 @default.
- W2079009086 cites W1989282172 @default.
- W2079009086 cites W1990388529 @default.
- W2079009086 cites W1992199057 @default.
- W2079009086 cites W1993068187 @default.
- W2079009086 cites W1993137505 @default.
- W2079009086 cites W1993320404 @default.
- W2079009086 cites W1996500123 @default.
- W2079009086 cites W1997387806 @default.
- W2079009086 cites W2000448219 @default.
- W2079009086 cites W2001196812 @default.
- W2079009086 cites W2002339398 @default.
- W2079009086 cites W2005032160 @default.
- W2079009086 cites W2007831460 @default.
- W2079009086 cites W2008857744 @default.
- W2079009086 cites W2010829605 @default.
- W2079009086 cites W2013655437 @default.
- W2079009086 cites W2014448534 @default.
- W2079009086 cites W2015484182 @default.
- W2079009086 cites W2021554745 @default.
- W2079009086 cites W2022099726 @default.
- W2079009086 cites W2024183517 @default.
- W2079009086 cites W2026267674 @default.
- W2079009086 cites W2027171495 @default.
- W2079009086 cites W2027740042 @default.
- W2079009086 cites W2031657999 @default.
- W2079009086 cites W2033166789 @default.
- W2079009086 cites W2039390777 @default.
- W2079009086 cites W2044220445 @default.
- W2079009086 cites W2044991970 @default.
- W2079009086 cites W2047685291 @default.
- W2079009086 cites W2048718744 @default.
- W2079009086 cites W2049683515 @default.
- W2079009086 cites W2049903091 @default.
- W2079009086 cites W2051638689 @default.
- W2079009086 cites W2053359936 @default.
- W2079009086 cites W2057063716 @default.
- W2079009086 cites W2057483830 @default.
- W2079009086 cites W2058910991 @default.
- W2079009086 cites W2062684472 @default.
- W2079009086 cites W2062883133 @default.
- W2079009086 cites W2064416917 @default.
- W2079009086 cites W2066503167 @default.
- W2079009086 cites W2066511972 @default.
- W2079009086 cites W2070413695 @default.
- W2079009086 cites W2072154498 @default.
- W2079009086 cites W2073128262 @default.
- W2079009086 cites W2073148375 @default.
- W2079009086 cites W2074355373 @default.
- W2079009086 cites W2077425962 @default.
- W2079009086 cites W2083806868 @default.
- W2079009086 cites W2085712847 @default.
- W2079009086 cites W2086591125 @default.
- W2079009086 cites W2087173041 @default.
- W2079009086 cites W2087769220 @default.
- W2079009086 cites W2089325811 @default.
- W2079009086 cites W2093349190 @default.
- W2079009086 cites W2093486927 @default.
- W2079009086 cites W2095077254 @default.
- W2079009086 cites W2096267165 @default.
- W2079009086 cites W2100743305 @default.
- W2079009086 cites W2101362443 @default.
- W2079009086 cites W2102050521 @default.