Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079009753> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2079009753 abstract "Non-ulcer dyspepsia (NUD) is one of the core functional bowel disorders. There has been recent emphasis on possible abnormal brain-gut interactions as being central to its pathophysiology. In this preliminary study, we examined central opioid tone in Helicobacter pylori-negative NUD patients using naloxone, an opioid antagonist, which stimulates pituitary-adrenal activity. The opioid system is known to govern nociceptive processing and to play a role in gut motor activity.Eight subjects with NUD and 8 age- and sex-matched healthy subjects were examined.Naloxone, 0.125 mg/kg, was administered at time 0. Adrenocorticotropin (ACTH) and cortisol responses were measured over a 120-min period. Maximum pituitary-adrenal responses in the 2 groups were compared.The ACTH response was significantly attenuated in the NUD group (p < 0.05). The cortisol response did not differ between the 2 groups (p = 0.7).Central opioid tone may be reduced in subjects with NUD. Our preliminary findings suggest that altered opioidergic activity may contribute to NUD pathophysiology, influencing the symptom profile through altered gut motor activity or possibly by influencing visceral sensitivity." @default.
- W2079009753 created "2016-06-24" @default.
- W2079009753 creator A5052566032 @default.
- W2079009753 creator A5065749390 @default.
- W2079009753 creator A5079343138 @default.
- W2079009753 creator A5087830456 @default.
- W2079009753 date "2002-01-01" @default.
- W2079009753 modified "2023-09-26" @default.
- W2079009753 title "Pituitary-Adrenal Response to Naloxone in Non-Ulcer Dyspepsia: Preliminary Evidence for a Reduction in Central Opioid Tone" @default.
- W2079009753 cites W1878753776 @default.
- W2079009753 cites W1952620523 @default.
- W2079009753 cites W1972258218 @default.
- W2079009753 cites W1978703741 @default.
- W2079009753 cites W1982769235 @default.
- W2079009753 cites W1989372656 @default.
- W2079009753 cites W1999803972 @default.
- W2079009753 cites W2012431985 @default.
- W2079009753 cites W2025852327 @default.
- W2079009753 cites W2026132680 @default.
- W2079009753 cites W2037026404 @default.
- W2079009753 cites W2044847871 @default.
- W2079009753 cites W2046364059 @default.
- W2079009753 cites W2069799736 @default.
- W2079009753 cites W2072114316 @default.
- W2079009753 cites W2072411460 @default.
- W2079009753 cites W2072572066 @default.
- W2079009753 cites W2085006035 @default.
- W2079009753 cites W2103736349 @default.
- W2079009753 cites W2118928491 @default.
- W2079009753 cites W2165886963 @default.
- W2079009753 cites W2222217957 @default.
- W2079009753 cites W2334848097 @default.
- W2079009753 cites W2419424939 @default.
- W2079009753 cites W2488512094 @default.
- W2079009753 cites W3008133184 @default.
- W2079009753 cites W67427124 @default.
- W2079009753 cites W70249653 @default.
- W2079009753 cites W1526502352 @default.
- W2079009753 doi "https://doi.org/10.1159/000057707" @default.
- W2079009753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12021479" @default.
- W2079009753 hasPublicationYear "2002" @default.
- W2079009753 type Work @default.
- W2079009753 sameAs 2079009753 @default.
- W2079009753 citedByCount "2" @default.
- W2079009753 crossrefType "journal-article" @default.
- W2079009753 hasAuthorship W2079009753A5052566032 @default.
- W2079009753 hasAuthorship W2079009753A5065749390 @default.
- W2079009753 hasAuthorship W2079009753A5079343138 @default.
- W2079009753 hasAuthorship W2079009753A5087830456 @default.
- W2079009753 hasConcept C124952713 @default.
- W2079009753 hasConcept C126322002 @default.
- W2079009753 hasConcept C134018914 @default.
- W2079009753 hasConcept C142362112 @default.
- W2079009753 hasConcept C170493617 @default.
- W2079009753 hasConcept C2778750930 @default.
- W2079009753 hasConcept C2780583480 @default.
- W2079009753 hasConcept C2781063702 @default.
- W2079009753 hasConcept C71924100 @default.
- W2079009753 hasConcept C88016717 @default.
- W2079009753 hasConceptScore W2079009753C124952713 @default.
- W2079009753 hasConceptScore W2079009753C126322002 @default.
- W2079009753 hasConceptScore W2079009753C134018914 @default.
- W2079009753 hasConceptScore W2079009753C142362112 @default.
- W2079009753 hasConceptScore W2079009753C170493617 @default.
- W2079009753 hasConceptScore W2079009753C2778750930 @default.
- W2079009753 hasConceptScore W2079009753C2780583480 @default.
- W2079009753 hasConceptScore W2079009753C2781063702 @default.
- W2079009753 hasConceptScore W2079009753C71924100 @default.
- W2079009753 hasConceptScore W2079009753C88016717 @default.
- W2079009753 hasLocation W20790097531 @default.
- W2079009753 hasLocation W20790097532 @default.
- W2079009753 hasOpenAccess W2079009753 @default.
- W2079009753 hasPrimaryLocation W20790097531 @default.
- W2079009753 hasRelatedWork W1567908657 @default.
- W2079009753 hasRelatedWork W1974076297 @default.
- W2079009753 hasRelatedWork W1976647719 @default.
- W2079009753 hasRelatedWork W1979844313 @default.
- W2079009753 hasRelatedWork W1983182328 @default.
- W2079009753 hasRelatedWork W1984242608 @default.
- W2079009753 hasRelatedWork W1988369402 @default.
- W2079009753 hasRelatedWork W1989579086 @default.
- W2079009753 hasRelatedWork W2014871043 @default.
- W2079009753 hasRelatedWork W2089573082 @default.
- W2079009753 hasRelatedWork W2098877656 @default.
- W2079009753 hasRelatedWork W2345839270 @default.
- W2079009753 hasRelatedWork W2417544006 @default.
- W2079009753 isParatext "false" @default.
- W2079009753 isRetracted "false" @default.
- W2079009753 magId "2079009753" @default.
- W2079009753 workType "article" @default.