FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079009895> ?p ?o ?g. }

• W2079009895 endingPage "e2819" @default.
• W2079009895 startingPage "e2819" @default.
• W2079009895 abstract "Background The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and apoptosis. Furthermore, in model organisms FOXOs act as tumor suppressors and affect aging. Previously, we noted that FOXOs and p53 are remarkably similar within their spectrum of regulatory proteins [1]. For example, the de-ubiquitinating enzyme USP7 removes ubiquitin from both FOXO and p53. However, Skp2 has been identified as E3 ligase for FOXO1, whereas Mdm2 is the prime E3 ligase for p53. Principal Findings/Methodology Here we provide evidence that Mdm2 acts as an E3 ligase for FOXO as well. In vitro incubation of Mdm2 and FOXO results in ATP-dependent (multi)mono-ubiquitination of FOXO similar to p53. Furthermore, in vivo co-expression of Mdm2 and FOXO induces FOXO mono-ubiquitination and consistent with this result, siRNA-mediated depletion of Mdm2 inhibits mono-ubiquitination of FOXO induced by hydrogen peroxide. Regulation of FOXO ubiquitination by Mdm2 is likely to be direct since Mdm2 and FOXO co-immunoprecipitate. In addition, Mdm2-mediated ubiquitination regulates FOXO transcriptional activity. Conclusions/Significance These data identify Mdm2 as a novel E3 ligase for FOXOs and extend the analogous mode of regulation between FOXO and p53." @default.
• W2079009895 created "2016-06-24" @default.
• W2079009895 creator A5004796853 @default.
• W2079009895 creator A5007701942 @default.
• W2079009895 creator A5033711163 @default.
• W2079009895 creator A5038107021 @default.
• W2079009895 creator A5042484749 @default.
• W2079009895 date "2008-07-30" @default.
• W2079009895 modified "2023-09-30" @default.
• W2079009895 title "Mdm2 Induces Mono-Ubiquitination of FOXO4" @default.
• W2079009895 cites W1494477854 @default.
• W2079009895 cites W1595390829 @default.
• W2079009895 cites W1625966995 @default.
• W2079009895 cites W1967334296 @default.
• W2079009895 cites W1967391569 @default.
• W2079009895 cites W1974178287 @default.
• W2079009895 cites W1996695017 @default.
• W2079009895 cites W2002568383 @default.
• W2079009895 cites W2005867401 @default.
• W2079009895 cites W2035188342 @default.
• W2079009895 cites W2041771374 @default.
• W2079009895 cites W2050745715 @default.
• W2079009895 cites W2056383938 @default.
• W2079009895 cites W2056402897 @default.
• W2079009895 cites W2058792851 @default.
• W2079009895 cites W2063877452 @default.
• W2079009895 cites W2081545299 @default.
• W2079009895 cites W2082852887 @default.
• W2079009895 cites W2095424116 @default.
• W2079009895 cites W2095659495 @default.
• W2079009895 cites W2098563852 @default.
• W2079009895 cites W2124898423 @default.
• W2079009895 cites W2126390187 @default.
• W2079009895 cites W2137035181 @default.
• W2079009895 cites W2163552821 @default.
• W2079009895 cites W2166525118 @default.
• W2079009895 cites W2315512556 @default.
• W2079009895 doi "https://doi.org/10.1371/journal.pone.0002819" @default.
• W2079009895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2475507" @default.
• W2079009895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18665269" @default.
• W2079009895 hasPublicationYear "2008" @default.
• W2079009895 type Work @default.
• W2079009895 sameAs 2079009895 @default.
• W2079009895 citedByCount "111" @default.
• W2079009895 countsByYear W20790098952012 @default.
• W2079009895 countsByYear W20790098952013 @default.
• W2079009895 countsByYear W20790098952014 @default.
• W2079009895 countsByYear W20790098952015 @default.
• W2079009895 countsByYear W20790098952016 @default.
• W2079009895 countsByYear W20790098952017 @default.
• W2079009895 countsByYear W20790098952018 @default.
• W2079009895 countsByYear W20790098952019 @default.
• W2079009895 countsByYear W20790098952020 @default.
• W2079009895 countsByYear W20790098952021 @default.
• W2079009895 countsByYear W20790098952022 @default.
• W2079009895 countsByYear W20790098952023 @default.
• W2079009895 crossrefType "journal-article" @default.
• W2079009895 hasAuthorship W2079009895A5004796853 @default.
• W2079009895 hasAuthorship W2079009895A5007701942 @default.
• W2079009895 hasAuthorship W2079009895A5033711163 @default.
• W2079009895 hasAuthorship W2079009895A5038107021 @default.
• W2079009895 hasAuthorship W2079009895A5042484749 @default.
• W2079009895 hasBestOaLocation W20790098951 @default.
• W2079009895 hasConcept C104317684 @default.
• W2079009895 hasConcept C11960822 @default.
• W2079009895 hasConcept C127561419 @default.
• W2079009895 hasConcept C134459356 @default.
• W2079009895 hasConcept C140149449 @default.
• W2079009895 hasConcept C175114707 @default.
• W2079009895 hasConcept C181199279 @default.
• W2079009895 hasConcept C185592680 @default.
• W2079009895 hasConcept C190283241 @default.
• W2079009895 hasConcept C25602115 @default.
• W2079009895 hasConcept C2776192174 @default.
• W2079009895 hasConcept C2776787872 @default.
• W2079009895 hasConcept C2908554999 @default.
• W2079009895 hasConcept C55493867 @default.
• W2079009895 hasConcept C75217442 @default.
• W2079009895 hasConcept C86339819 @default.
• W2079009895 hasConcept C86803240 @default.
• W2079009895 hasConcept C95444343 @default.
• W2079009895 hasConceptScore W2079009895C104317684 @default.
• W2079009895 hasConceptScore W2079009895C11960822 @default.
• W2079009895 hasConceptScore W2079009895C127561419 @default.
• W2079009895 hasConceptScore W2079009895C134459356 @default.
• W2079009895 hasConceptScore W2079009895C140149449 @default.
• W2079009895 hasConceptScore W2079009895C175114707 @default.
• W2079009895 hasConceptScore W2079009895C181199279 @default.
• W2079009895 hasConceptScore W2079009895C185592680 @default.
• W2079009895 hasConceptScore W2079009895C190283241 @default.
• W2079009895 hasConceptScore W2079009895C25602115 @default.
• W2079009895 hasConceptScore W2079009895C2776192174 @default.
• W2079009895 hasConceptScore W2079009895C2776787872 @default.
• W2079009895 hasConceptScore W2079009895C2908554999 @default.
• W2079009895 hasConceptScore W2079009895C55493867 @default.
• W2079009895 hasConceptScore W2079009895C75217442 @default.
• W2079009895 hasConceptScore W2079009895C86339819 @default.
• W2079009895 hasConceptScore W2079009895C86803240 @default.

• next