Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079014559> ?p ?o ?g. }
- W2079014559 endingPage "122" @default.
- W2079014559 startingPage "113" @default.
- W2079014559 abstract "Both repeated stress and corticosterone administration induce remodeling of apical dendrites of hippocampal CA3 pyramidal neurons. Circulating glucocorticoids are involved in the mechanism that produces atrophy, along with excitatory amino acids and serotonin (5-hydroxytryptamine, 5-HT). We used 5-HT-related antidepressants and a benzodiazepine in order to explore indirectly the role of serotonin and GABAA-benzodiazepine receptors in the stress-induced structural changes visualized by the Golgi impregnation of the rat hippocampus. The 5-HT reuptake enhancer (±)-tianeptine prevented the dendritic atrophy caused by repeated restraint stress in a non-stereoselective fashion and two 5-HT reuptake antagonists, fluoxetine and fluvoxamine, failed to block dendritic atrophy. Tianeptine also functions as a therapeutic tool since it reversed the already established hippocampal atrophy caused by treatment with corticosterone for 3 weeks. Finally, the benzodiazepine agonist adinazolam was effective in preventing the stress-induced dendritic atrophy. These findings suggest that the synaptic availability of 5-HT is involved in the mechanism leading to stress-induced dendritic remodeling and supports the idea that the hippocampal inhibitory GABAergic tone may play a regulatory role." @default.
- W2079014559 created "2016-06-24" @default.
- W2079014559 creator A5019627539 @default.
- W2079014559 creator A5021349263 @default.
- W2079014559 creator A5035103174 @default.
- W2079014559 date "1999-04-01" @default.
- W2079014559 modified "2023-09-24" @default.
- W2079014559 title "Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress" @default.
- W2079014559 cites W170792860 @default.
- W2079014559 cites W1804267428 @default.
- W2079014559 cites W1881281756 @default.
- W2079014559 cites W1969484228 @default.
- W2079014559 cites W1974956398 @default.
- W2079014559 cites W1977249405 @default.
- W2079014559 cites W1977550486 @default.
- W2079014559 cites W1977977170 @default.
- W2079014559 cites W1981724466 @default.
- W2079014559 cites W1985032255 @default.
- W2079014559 cites W1988957190 @default.
- W2079014559 cites W1990243312 @default.
- W2079014559 cites W1994048221 @default.
- W2079014559 cites W1997898582 @default.
- W2079014559 cites W1998357797 @default.
- W2079014559 cites W1999391547 @default.
- W2079014559 cites W2000622630 @default.
- W2079014559 cites W2001328720 @default.
- W2079014559 cites W2004643104 @default.
- W2079014559 cites W2016966416 @default.
- W2079014559 cites W2017124867 @default.
- W2079014559 cites W2017471052 @default.
- W2079014559 cites W2019316537 @default.
- W2079014559 cites W2024583667 @default.
- W2079014559 cites W2025381319 @default.
- W2079014559 cites W2027218203 @default.
- W2079014559 cites W2031646291 @default.
- W2079014559 cites W2034694738 @default.
- W2079014559 cites W2035266273 @default.
- W2079014559 cites W2038465691 @default.
- W2079014559 cites W2038665328 @default.
- W2079014559 cites W2043636380 @default.
- W2079014559 cites W2045059056 @default.
- W2079014559 cites W2046602660 @default.
- W2079014559 cites W2050917344 @default.
- W2079014559 cites W2052225153 @default.
- W2079014559 cites W2054409515 @default.
- W2079014559 cites W2055065216 @default.
- W2079014559 cites W2057658065 @default.
- W2079014559 cites W2058178532 @default.
- W2079014559 cites W2060589548 @default.
- W2079014559 cites W2061845384 @default.
- W2079014559 cites W2068427778 @default.
- W2079014559 cites W2070491370 @default.
- W2079014559 cites W2070936554 @default.
- W2079014559 cites W2073531245 @default.
- W2079014559 cites W2076639163 @default.
- W2079014559 cites W2083659148 @default.
- W2079014559 cites W2085380618 @default.
- W2079014559 cites W2089579499 @default.
- W2079014559 cites W2152541584 @default.
- W2079014559 cites W2159699558 @default.
- W2079014559 cites W2160282214 @default.
- W2079014559 cites W2165278596 @default.
- W2079014559 cites W2397426560 @default.
- W2079014559 cites W4237348831 @default.
- W2079014559 cites W4319425380 @default.
- W2079014559 doi "https://doi.org/10.1016/s0014-2999(99)00163-6" @default.
- W2079014559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10357248" @default.
- W2079014559 hasPublicationYear "1999" @default.
- W2079014559 type Work @default.
- W2079014559 sameAs 2079014559 @default.
- W2079014559 citedByCount "308" @default.
- W2079014559 countsByYear W20790145592012 @default.
- W2079014559 countsByYear W20790145592013 @default.
- W2079014559 countsByYear W20790145592014 @default.
- W2079014559 countsByYear W20790145592015 @default.
- W2079014559 countsByYear W20790145592016 @default.
- W2079014559 countsByYear W20790145592017 @default.
- W2079014559 countsByYear W20790145592018 @default.
- W2079014559 countsByYear W20790145592019 @default.
- W2079014559 countsByYear W20790145592020 @default.
- W2079014559 countsByYear W20790145592021 @default.
- W2079014559 countsByYear W20790145592022 @default.
- W2079014559 countsByYear W20790145592023 @default.
- W2079014559 crossrefType "journal-article" @default.
- W2079014559 hasAuthorship W2079014559A5019627539 @default.
- W2079014559 hasAuthorship W2079014559A5021349263 @default.
- W2079014559 hasAuthorship W2079014559A5035103174 @default.
- W2079014559 hasConcept C126322002 @default.
- W2079014559 hasConcept C134018914 @default.
- W2079014559 hasConcept C148762608 @default.
- W2079014559 hasConcept C15744967 @default.
- W2079014559 hasConcept C168258287 @default.
- W2079014559 hasConcept C169760540 @default.
- W2079014559 hasConcept C170493617 @default.
- W2079014559 hasConcept C17077164 @default.
- W2079014559 hasConcept C185592680 @default.
- W2079014559 hasConcept C2775864247 @default.
- W2079014559 hasConcept C2776134451 @default.