FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079017842> ?p ?o ?g. }

• W2079017842 endingPage "1583" @default.
• W2079017842 startingPage "1574" @default.
• W2079017842 abstract "Vectors based on human adenovirus (Ad) and adeno-associated virus (AAV) are being evaluated for human gene therapy. The response of the host to the vector, in terms of antigen-specific immunity, will play a substantial role in clinical outcome. We have surveyed cohorts of normal subjects and cystic fibrosis patients for pre-existing immunity to these viruses, caused by naturally acquired infections. A number of humoral and cellular assays to adenovirus serotype 5 (Ad5) and adeno-associated virus serotype 2 (AAV2) were performed from serum and peripheral blood mononuclear cells. Virtually all subjects had Ig to Ad5 although only 55% of these antibodies neutralized virus (NAB). Approximately two of three patients demonstrated CD4+ T cells that proliferated to Ad antigens of which most were of the TH1 subset, based on cytokine secretion. A substantially different pattern of immune responses was observed to AAV2. Although virtually all patients had Ig to AAV2, most of these antibodies were not neutralizing (32% NAB) and only 5% of patients had peripheral blood lymphocytes that proliferated in response to AAV2 antigens. These studies demonstrate marked heterogeneity in pre-existing immunity to Ad5 and AAV2 in human populations. The impact of these findings on outcome following gene therapy will require further study." @default.
• W2079017842 created "2016-06-24" @default.
• W2079017842 creator A5011305628 @default.
• W2079017842 creator A5011536972 @default.
• W2079017842 creator A5051344823 @default.
• W2079017842 creator A5052804474 @default.
• W2079017842 creator A5070314915 @default.
• W2079017842 creator A5089332134 @default.
• W2079017842 date "1999-09-01" @default.
• W2079017842 modified "2023-10-12" @default.
• W2079017842 title "Immune responses to adenovirus and adeno-associated virus in humans" @default.
• W2079017842 cites W140162132 @default.
• W2079017842 cites W1499346340 @default.
• W2079017842 cites W1519383882 @default.
• W2079017842 cites W1550123562 @default.
• W2079017842 cites W1942870285 @default.
• W2079017842 cites W1943760307 @default.
• W2079017842 cites W1968006472 @default.
• W2079017842 cites W1970959631 @default.
• W2079017842 cites W1972832005 @default.
• W2079017842 cites W1984183779 @default.
• W2079017842 cites W1997659110 @default.
• W2079017842 cites W2007854533 @default.
• W2079017842 cites W2015617337 @default.
• W2079017842 cites W2031112206 @default.
• W2079017842 cites W2031501484 @default.
• W2079017842 cites W2032847261 @default.
• W2079017842 cites W2048303863 @default.
• W2079017842 cites W2055468162 @default.
• W2079017842 cites W2080094805 @default.
• W2079017842 cites W2081484258 @default.
• W2079017842 cites W2090781939 @default.
• W2079017842 cites W2090983403 @default.
• W2079017842 cites W2129859001 @default.
• W2079017842 cites W2143836588 @default.
• W2079017842 cites W2164928522 @default.
• W2079017842 cites W2313269464 @default.
• W2079017842 cites W4313308310 @default.
• W2079017842 doi "https://doi.org/10.1038/sj.gt.3300994" @default.
• W2079017842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10490767" @default.
• W2079017842 hasPublicationYear "1999" @default.
• W2079017842 type Work @default.
• W2079017842 sameAs 2079017842 @default.
• W2079017842 citedByCount "637" @default.
• W2079017842 countsByYear W20790178422012 @default.
• W2079017842 countsByYear W20790178422013 @default.
• W2079017842 countsByYear W20790178422014 @default.
• W2079017842 countsByYear W20790178422015 @default.
• W2079017842 countsByYear W20790178422016 @default.
• W2079017842 countsByYear W20790178422017 @default.
• W2079017842 countsByYear W20790178422018 @default.
• W2079017842 countsByYear W20790178422019 @default.
• W2079017842 countsByYear W20790178422020 @default.
• W2079017842 countsByYear W20790178422021 @default.
• W2079017842 countsByYear W20790178422022 @default.
• W2079017842 countsByYear W20790178422023 @default.
• W2079017842 crossrefType "journal-article" @default.
• W2079017842 hasAuthorship W2079017842A5011305628 @default.
• W2079017842 hasAuthorship W2079017842A5011536972 @default.
• W2079017842 hasAuthorship W2079017842A5051344823 @default.
• W2079017842 hasAuthorship W2079017842A5052804474 @default.
• W2079017842 hasAuthorship W2079017842A5070314915 @default.
• W2079017842 hasAuthorship W2079017842A5089332134 @default.
• W2079017842 hasBestOaLocation W20790178421 @default.
• W2079017842 hasConcept C10389963 @default.
• W2079017842 hasConcept C104317684 @default.
• W2079017842 hasConcept C111599444 @default.
• W2079017842 hasConcept C137061746 @default.
• W2079017842 hasConcept C147483822 @default.
• W2079017842 hasConcept C159047783 @default.
• W2079017842 hasConcept C159654299 @default.
• W2079017842 hasConcept C202751555 @default.
• W2079017842 hasConcept C203014093 @default.
• W2079017842 hasConcept C2522874641 @default.
• W2079017842 hasConcept C2776548049 @default.
• W2079017842 hasConcept C2776954459 @default.
• W2079017842 hasConcept C2778107364 @default.
• W2079017842 hasConcept C2779341262 @default.
• W2079017842 hasConcept C3017875465 @default.
• W2079017842 hasConcept C40767141 @default.
• W2079017842 hasConcept C55493867 @default.
• W2079017842 hasConcept C86803240 @default.
• W2079017842 hasConcept C8891405 @default.
• W2079017842 hasConcept C92087593 @default.
• W2079017842 hasConceptScore W2079017842C10389963 @default.
• W2079017842 hasConceptScore W2079017842C104317684 @default.
• W2079017842 hasConceptScore W2079017842C111599444 @default.
• W2079017842 hasConceptScore W2079017842C137061746 @default.
• W2079017842 hasConceptScore W2079017842C147483822 @default.
• W2079017842 hasConceptScore W2079017842C159047783 @default.
• W2079017842 hasConceptScore W2079017842C159654299 @default.
• W2079017842 hasConceptScore W2079017842C202751555 @default.
• W2079017842 hasConceptScore W2079017842C203014093 @default.
• W2079017842 hasConceptScore W2079017842C2522874641 @default.
• W2079017842 hasConceptScore W2079017842C2776548049 @default.
• W2079017842 hasConceptScore W2079017842C2776954459 @default.
• W2079017842 hasConceptScore W2079017842C2778107364 @default.
• W2079017842 hasConceptScore W2079017842C2779341262 @default.

• next