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- W2079018293 abstract "The gene (mga4) encoding the positive regulatory protein, Mga4, was cloned and sequenced from an M type 4 strain (AP4) of Streptococcus pyogenes. The deduced amino acid (aa) sequence of this ‘divergent Mga’ shows 88% identity to the prototype Mgal in its N-terminal half, which contains all three of the predicted helix-turn-helix domains. However, one of the predicted receiver domains of Mgal, which is at its C terminus, is not conserved in the Mga4 aa sequence. Nevertheless, a mutation in mgal was found to be complemented for activation of the gene encoding M protein (emm) by mga4 in trans. This suggests that the aa residues of the C-terminal predicted receiver domain are not critical for activation of emm transcription." @default.
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- W2079018293 date "1996-10-01" @default.
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- W2079018293 title "Complementation of divergent mga genes in group A Streptococcus" @default.
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- W2079018293 doi "https://doi.org/10.1016/0378-1119(96)00124-2" @default.
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