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- W2079034071 abstract "(1R)-1-Deuterated alcohols with high enantiomeric excess were prepared via TiCl4/Et3SiD reduction of acetals arising from the reaction of aldehydes with (1S,2S)-3,3,3-trifluoro-1-phenylpropane-1,2-diol 9. Such a chiral auxiliary was synthesized in an enantiomerically pure form starting from l-mandelic acid. Due to its benzylic nature, it was easily removed from the reaction product of the reductive 1,3-dioxolane ring-cleavage to afford the desired α-deuterated alcohol." @default.
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- W2079034071 date "2009-02-01" @default.
- W2079034071 modified "2023-10-09" @default.
- W2079034071 title "Convenient synthesis of optically active deuterated primary alcohols via deuteride reduction of acetals derived from homochiral (1R∗,2R∗)-3,3,3-trifluoro-1-phenylpropane-1,2-diols" @default.
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- W2079034071 doi "https://doi.org/10.1016/j.tetasy.2009.01.020" @default.
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