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- W2079040357 abstract "Escherichia coli B, strain AS19, is sensitive to fusidic acid, a drug which inhibits ribosome translocation. At low concentrations of fusidic acid (0.1 and 0.25 μg/ml) the drug was concentrated approximately 50 times inside the cell and exponential growth at a reduced rate was established after a transient lasting 60 to 90 minutes. In the presence of fusidic acid the ribosomal proteins (as a proportion of total protein) comprise a greater fraction of total protein, and the stable RNA species are accumulated at a higher rate than in control cultures; furthermore the pool of ppGpp is lower. These results show that direct, but partial inhibition of protein synthesis by fusidic acid causes a shift-down in terms of growth rate coupled with a change in cell composition similar to that seen after a shift-up." @default.
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- W2079040357 date "1974-12-01" @default.
- W2079040357 modified "2023-10-03" @default.
- W2079040357 title "The effects of fusidic acid on growth, ribosome synthesis and RNA metabolism in Escherichia coli" @default.
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- W2079040357 doi "https://doi.org/10.1016/0022-2836(74)90234-4" @default.
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