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- W2079046810 startingPage "4886" @default.
- W2079046810 abstract "How mechanical forces are sensed remains largely mysterious. The forces that gate prokaryotic and several eukaryotic channels were found to come from the lipid membrane. Our survey of animal cells found that membrane force foci all have cholesterol-gathering proteins and are reinforced with cholesterol. This result is evident in overt force sensors at the tips of stereocilia for vertebrate hearing and the touch receptor of Caenorhabditis elegans and mammalian neurons. For less specialized cells, cadherins sustain the force between neighboring cells and integrins between cells and matrix. These tension bearers also pass through and bind to a cholesterol-enriched platform before anchoring to cytoskeleton through other proteins. Cholesterol, in alliance with sphingomyelin and specialized proteins, enforces a more ordered structure in the bilayer. Such a stiffened platform can suppress mechanical noise, redirect, rescale, and confine force. We speculate that such platforms may be dynamic. The applied force may allow disordered-phase lipids to enter the platform-staging channel opening in the thinner mobile neighborhood. The platform may also contain specialized protein/lipid subdomains enclosing mechanosensitive channels to open with localized tension. Such a dynamic stage can mechanically operate structurally disparate channels or enzymes without having to tie them directly to cadherin, integrin, or other protein tethers." @default.
- W2079046810 created "2016-06-24" @default.
- W2079046810 creator A5051855350 @default.
- W2079046810 creator A5076045409 @default.
- W2079046810 date "2013-03-08" @default.
- W2079046810 modified "2023-10-13" @default.
- W2079046810 title "Stiffened lipid platforms at molecular force foci" @default.
- W2079046810 cites W1497754562 @default.
- W2079046810 cites W1533368723 @default.
- W2079046810 cites W1971642414 @default.
- W2079046810 cites W1972807210 @default.
- W2079046810 cites W1974216293 @default.
- W2079046810 cites W1975461211 @default.
- W2079046810 cites W1981944321 @default.
- W2079046810 cites W1987223530 @default.
- W2079046810 cites W1995435834 @default.
- W2079046810 cites W1996895789 @default.
- W2079046810 cites W1997766063 @default.
- W2079046810 cites W1999032092 @default.
- W2079046810 cites W1999720993 @default.
- W2079046810 cites W2000382733 @default.
- W2079046810 cites W2003698382 @default.
- W2079046810 cites W2007168806 @default.
- W2079046810 cites W2008305695 @default.
- W2079046810 cites W2008312998 @default.
- W2079046810 cites W2010721093 @default.
- W2079046810 cites W2011366802 @default.
- W2079046810 cites W2012608189 @default.
- W2079046810 cites W2013711061 @default.
- W2079046810 cites W2014895510 @default.
- W2079046810 cites W2017949750 @default.
- W2079046810 cites W2017978290 @default.
- W2079046810 cites W2020705112 @default.
- W2079046810 cites W2022714443 @default.
- W2079046810 cites W2023239777 @default.
- W2079046810 cites W2024548186 @default.
- W2079046810 cites W2025993347 @default.
- W2079046810 cites W2033575799 @default.
- W2079046810 cites W2033980199 @default.
- W2079046810 cites W2034252968 @default.
- W2079046810 cites W2036735222 @default.
- W2079046810 cites W2037249963 @default.
- W2079046810 cites W2038454082 @default.
- W2079046810 cites W2041345208 @default.
- W2079046810 cites W2043559270 @default.
- W2079046810 cites W2044995190 @default.
- W2079046810 cites W2047749946 @default.
- W2079046810 cites W2047841553 @default.
- W2079046810 cites W2048009063 @default.
- W2079046810 cites W2048305477 @default.
- W2079046810 cites W2050575405 @default.
- W2079046810 cites W2051545925 @default.
- W2079046810 cites W2054342311 @default.
- W2079046810 cites W2055920457 @default.
- W2079046810 cites W2056248793 @default.
- W2079046810 cites W2057360937 @default.
- W2079046810 cites W2059571424 @default.
- W2079046810 cites W2060877976 @default.
- W2079046810 cites W2067573008 @default.
- W2079046810 cites W2074213768 @default.
- W2079046810 cites W2076086205 @default.
- W2079046810 cites W2076141253 @default.
- W2079046810 cites W2077797668 @default.
- W2079046810 cites W2077891508 @default.
- W2079046810 cites W2078995260 @default.
- W2079046810 cites W2080438773 @default.
- W2079046810 cites W2082272068 @default.
- W2079046810 cites W2086354121 @default.
- W2079046810 cites W2091719660 @default.
- W2079046810 cites W2093668760 @default.
- W2079046810 cites W2097299035 @default.
- W2079046810 cites W2097654444 @default.
- W2079046810 cites W2100139666 @default.
- W2079046810 cites W2103905377 @default.
- W2079046810 cites W2104139776 @default.
- W2079046810 cites W2108560778 @default.
- W2079046810 cites W2110176960 @default.
- W2079046810 cites W2112745316 @default.
- W2079046810 cites W2113263416 @default.
- W2079046810 cites W2125041118 @default.
- W2079046810 cites W2130044053 @default.
- W2079046810 cites W2131717149 @default.
- W2079046810 cites W2134135483 @default.
- W2079046810 cites W2136558879 @default.
- W2079046810 cites W2136638991 @default.
- W2079046810 cites W2145842550 @default.
- W2079046810 cites W2147869016 @default.
- W2079046810 cites W2148294117 @default.
- W2079046810 cites W2152033204 @default.
- W2079046810 cites W2156629407 @default.
- W2079046810 cites W2157194890 @default.
- W2079046810 cites W2159760243 @default.
- W2079046810 cites W2161897058 @default.
- W2079046810 cites W2162859992 @default.
- W2079046810 cites W4256264544 @default.
- W2079046810 doi "https://doi.org/10.1073/pnas.1302018110" @default.
- W2079046810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3612676" @default.
- W2079046810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23476066" @default.