FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079051338> ?p ?o ?g. }

• W2079051338 endingPage "1711" @default.
• W2079051338 startingPage "1703" @default.
• W2079051338 abstract "Nitric oxide generated by nitric oxide synthases (NOSs) can react with reactive oxygen species (ROS), forming peroxynitrite, which may contribute to the ROS-initiated macromolecular damage implicated in the embryopathic effects of both endogenous and drug-enhanced oxidative stress. Inducible NOS (iNOS) is nonconstitutive in most tissues, and its embryonic expression and developmental importance are unknown. Herein, during organogenesis (Gestational Days 9 and 10), wild-type B6129PF2 embryos in culture were highly susceptible to the ROS-initiating teratogens phenytoin and benzo[a]pyrene, whereas iNOS knockout embryos were substantially but not completely protected (p < .05), implicating iNOS in the embryopathic mechanism. However, in contrast to prostaglandin H synthase-catalyzed teratogen bioactivation and ROS formation, which occurs within the embryo, in vivo iNOS expression was limited to placental tissue. These results suggest that the diffusion of nitric oxide from placental progenitor tissue (ectoplacental cone) to embryonic target tissues contributes to the embryopathic effects of ROS-initiating teratogens in embryo culture, which may constitute a mechanism by which embryonic determinants of ROS-mediated teratogenesis can be modulated by maternal extra-embryonic processes." @default.
• W2079051338 created "2016-06-24" @default.
• W2079051338 creator A5003013729 @default.
• W2079051338 creator A5072894260 @default.
• W2079051338 creator A5085173722 @default.
• W2079051338 creator A5090741712 @default.
• W2079051338 date "2004-12-01" @default.
• W2079051338 modified "2023-10-16" @default.
• W2079051338 title "The peroxynitrite pathway in development: Phenytoin and benzo[a]pyrene embryopathies in inducible nitric oxide synthase knockout mice" @default.
• W2079051338 cites W1106257837 @default.
• W2079051338 cites W1535461485 @default.
• W2079051338 cites W1974185399 @default.
• W2079051338 cites W1977584817 @default.
• W2079051338 cites W1989591670 @default.
• W2079051338 cites W1999444895 @default.
• W2079051338 cites W2000068361 @default.
• W2079051338 cites W2003135129 @default.
• W2079051338 cites W2007796985 @default.
• W2079051338 cites W2015839427 @default.
• W2079051338 cites W2025773145 @default.
• W2079051338 cites W2049253299 @default.
• W2079051338 cites W2072688910 @default.
• W2079051338 cites W2075553027 @default.
• W2079051338 cites W2083149447 @default.
• W2079051338 cites W2093695182 @default.
• W2079051338 cites W2095495320 @default.
• W2079051338 cites W2100837269 @default.
• W2079051338 cites W2101108802 @default.
• W2079051338 cites W2109186493 @default.
• W2079051338 cites W2111806753 @default.
• W2079051338 cites W2122877713 @default.
• W2079051338 cites W2126624423 @default.
• W2079051338 cites W2140936548 @default.
• W2079051338 cites W2147676673 @default.
• W2079051338 cites W2156438193 @default.
• W2079051338 cites W2159132498 @default.
• W2079051338 cites W2356484699 @default.
• W2079051338 cites W4246057271 @default.
• W2079051338 cites W90432907 @default.
• W2079051338 doi "https://doi.org/10.1016/j.freeradbiomed.2004.08.004" @default.
• W2079051338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15528029" @default.
• W2079051338 hasPublicationYear "2004" @default.
• W2079051338 type Work @default.
• W2079051338 sameAs 2079051338 @default.
• W2079051338 citedByCount "34" @default.
• W2079051338 countsByYear W20790513382013 @default.
• W2079051338 countsByYear W20790513382014 @default.
• W2079051338 countsByYear W20790513382015 @default.
• W2079051338 countsByYear W20790513382016 @default.
• W2079051338 countsByYear W20790513382017 @default.
• W2079051338 countsByYear W20790513382018 @default.
• W2079051338 countsByYear W20790513382019 @default.
• W2079051338 countsByYear W20790513382022 @default.
• W2079051338 crossrefType "journal-article" @default.
• W2079051338 hasAuthorship W2079051338A5003013729 @default.
• W2079051338 hasAuthorship W2079051338A5072894260 @default.
• W2079051338 hasAuthorship W2079051338A5085173722 @default.
• W2079051338 hasAuthorship W2079051338A5090741712 @default.
• W2079051338 hasConcept C170493617 @default.
• W2079051338 hasConcept C172680121 @default.
• W2079051338 hasConcept C178790620 @default.
• W2079051338 hasConcept C179335377 @default.
• W2079051338 hasConcept C181199279 @default.
• W2079051338 hasConcept C182704531 @default.
• W2079051338 hasConcept C185592680 @default.
• W2079051338 hasConcept C2776151105 @default.
• W2079051338 hasConcept C2777622882 @default.
• W2079051338 hasConcept C2778784160 @default.
• W2079051338 hasConcept C2779234561 @default.
• W2079051338 hasConcept C2779525624 @default.
• W2079051338 hasConcept C2780795997 @default.
• W2079051338 hasConcept C48349386 @default.
• W2079051338 hasConcept C519581460 @default.
• W2079051338 hasConcept C54355233 @default.
• W2079051338 hasConcept C55493867 @default.
• W2079051338 hasConcept C65290608 @default.
• W2079051338 hasConcept C86803240 @default.
• W2079051338 hasConcept C95444343 @default.
• W2079051338 hasConceptScore W2079051338C170493617 @default.
• W2079051338 hasConceptScore W2079051338C172680121 @default.
• W2079051338 hasConceptScore W2079051338C178790620 @default.
• W2079051338 hasConceptScore W2079051338C179335377 @default.
• W2079051338 hasConceptScore W2079051338C181199279 @default.
• W2079051338 hasConceptScore W2079051338C182704531 @default.
• W2079051338 hasConceptScore W2079051338C185592680 @default.
• W2079051338 hasConceptScore W2079051338C2776151105 @default.
• W2079051338 hasConceptScore W2079051338C2777622882 @default.
• W2079051338 hasConceptScore W2079051338C2778784160 @default.
• W2079051338 hasConceptScore W2079051338C2779234561 @default.
• W2079051338 hasConceptScore W2079051338C2779525624 @default.
• W2079051338 hasConceptScore W2079051338C2780795997 @default.
• W2079051338 hasConceptScore W2079051338C48349386 @default.
• W2079051338 hasConceptScore W2079051338C519581460 @default.
• W2079051338 hasConceptScore W2079051338C54355233 @default.
• W2079051338 hasConceptScore W2079051338C55493867 @default.
• W2079051338 hasConceptScore W2079051338C65290608 @default.
• W2079051338 hasConceptScore W2079051338C86803240 @default.
• W2079051338 hasConceptScore W2079051338C95444343 @default.

• next