Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079054128> ?p ?o ?g. }
- W2079054128 endingPage "358" @default.
- W2079054128 startingPage "353" @default.
- W2079054128 abstract "Phosphatidylinositol 3′-kinase (PI3K) and Akt mediate survival signals and allow the cells to escape apoptosis in various human cancers. We postulated that LY294002, a PI3K inhibitor, might inactivate Akt, consequently inhibiting cell proliferation in 3 human pancreatic ductal carcinoma cell lines, PSN-1, PANC-1, and KP-4. LY294002 (50 μmol/L) caused a decrease in phosphorylated Akt and inhibition of cell proliferation in a time-dependent manner, but there was no obvious induction of apoptosis. Flow cytometric analysis revealed that pancreatic cancer cells treated with 50 μmol/L LY294002 underwent G1 arrest, which was associated with dephosphorylation of the ppRB protein, a decrease in the protein expression of cyclin D and E, and their activating partners Cdk2, 4, and 6 with simultaneous accumulation of P27/Kip1. Our data indicate that P27/Kip1 accumulation by Akt inactivation could induce cell cycle arrest in the G1 phase and suggest that the PI3K-Akt pathway plays an important role in cell proliferation in human pancreatic ductal carcinoma cells." @default.
- W2079054128 created "2016-06-24" @default.
- W2079054128 creator A5026564012 @default.
- W2079054128 creator A5027124429 @default.
- W2079054128 creator A5033310099 @default.
- W2079054128 creator A5055999797 @default.
- W2079054128 creator A5090384790 @default.
- W2079054128 date "2004-04-01" @default.
- W2079054128 modified "2023-10-18" @default.
- W2079054128 title "Role of the Phosphatidylinositol 3???-Kinase???Akt Signal Pathway in the Proliferation of Human Pancreatic Ductal Carcinoma Cell Lines" @default.
- W2079054128 cites W1529396499 @default.
- W2079054128 cites W1970779989 @default.
- W2079054128 cites W1972794819 @default.
- W2079054128 cites W1977647141 @default.
- W2079054128 cites W1980123375 @default.
- W2079054128 cites W1981517713 @default.
- W2079054128 cites W1995124037 @default.
- W2079054128 cites W2001458398 @default.
- W2079054128 cites W2002179434 @default.
- W2079054128 cites W2004078164 @default.
- W2079054128 cites W2013856642 @default.
- W2079054128 cites W2024306318 @default.
- W2079054128 cites W2025970479 @default.
- W2079054128 cites W2027719459 @default.
- W2079054128 cites W2033801757 @default.
- W2079054128 cites W2044868069 @default.
- W2079054128 cites W2055154941 @default.
- W2079054128 cites W2059692699 @default.
- W2079054128 cites W2062860025 @default.
- W2079054128 cites W2065982982 @default.
- W2079054128 cites W2091403769 @default.
- W2079054128 cites W2097767970 @default.
- W2079054128 cites W2111613650 @default.
- W2079054128 cites W2121619780 @default.
- W2079054128 cites W2123504758 @default.
- W2079054128 cites W2136085413 @default.
- W2079054128 cites W2164034599 @default.
- W2079054128 cites W4231031590 @default.
- W2079054128 cites W46228081 @default.
- W2079054128 doi "https://doi.org/10.1097/00006676-200404000-00026" @default.
- W2079054128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15084985" @default.
- W2079054128 hasPublicationYear "2004" @default.
- W2079054128 type Work @default.
- W2079054128 sameAs 2079054128 @default.
- W2079054128 citedByCount "47" @default.
- W2079054128 countsByYear W20790541282012 @default.
- W2079054128 countsByYear W20790541282014 @default.
- W2079054128 countsByYear W20790541282015 @default.
- W2079054128 countsByYear W20790541282016 @default.
- W2079054128 countsByYear W20790541282021 @default.
- W2079054128 crossrefType "journal-article" @default.
- W2079054128 hasAuthorship W2079054128A5026564012 @default.
- W2079054128 hasAuthorship W2079054128A5027124429 @default.
- W2079054128 hasAuthorship W2079054128A5033310099 @default.
- W2079054128 hasAuthorship W2079054128A5055999797 @default.
- W2079054128 hasAuthorship W2079054128A5090384790 @default.
- W2079054128 hasConcept C184235292 @default.
- W2079054128 hasConcept C185592680 @default.
- W2079054128 hasConcept C190283241 @default.
- W2079054128 hasConcept C2776912716 @default.
- W2079054128 hasConcept C2780610907 @default.
- W2079054128 hasConcept C29537977 @default.
- W2079054128 hasConcept C502942594 @default.
- W2079054128 hasConcept C55493867 @default.
- W2079054128 hasConcept C62112901 @default.
- W2079054128 hasConcept C62478195 @default.
- W2079054128 hasConcept C75217442 @default.
- W2079054128 hasConcept C82495950 @default.
- W2079054128 hasConcept C86554907 @default.
- W2079054128 hasConcept C86803240 @default.
- W2079054128 hasConcept C95444343 @default.
- W2079054128 hasConceptScore W2079054128C184235292 @default.
- W2079054128 hasConceptScore W2079054128C185592680 @default.
- W2079054128 hasConceptScore W2079054128C190283241 @default.
- W2079054128 hasConceptScore W2079054128C2776912716 @default.
- W2079054128 hasConceptScore W2079054128C2780610907 @default.
- W2079054128 hasConceptScore W2079054128C29537977 @default.
- W2079054128 hasConceptScore W2079054128C502942594 @default.
- W2079054128 hasConceptScore W2079054128C55493867 @default.
- W2079054128 hasConceptScore W2079054128C62112901 @default.
- W2079054128 hasConceptScore W2079054128C62478195 @default.
- W2079054128 hasConceptScore W2079054128C75217442 @default.
- W2079054128 hasConceptScore W2079054128C82495950 @default.
- W2079054128 hasConceptScore W2079054128C86554907 @default.
- W2079054128 hasConceptScore W2079054128C86803240 @default.
- W2079054128 hasConceptScore W2079054128C95444343 @default.
- W2079054128 hasIssue "3" @default.
- W2079054128 hasLocation W20790541281 @default.
- W2079054128 hasLocation W20790541282 @default.
- W2079054128 hasOpenAccess W2079054128 @default.
- W2079054128 hasPrimaryLocation W20790541281 @default.
- W2079054128 hasRelatedWork W2020067517 @default.
- W2079054128 hasRelatedWork W2051069156 @default.
- W2079054128 hasRelatedWork W2124592445 @default.
- W2079054128 hasRelatedWork W2169339192 @default.
- W2079054128 hasRelatedWork W2278983970 @default.
- W2079054128 hasRelatedWork W2356558710 @default.
- W2079054128 hasRelatedWork W2438578109 @default.