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- W2079055190 abstract "A high prevalence of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin's lymphoma (B-NHL) has been reported in some, but not all, studies, and the association showed a strong regional variation. We conducted a systematic review of the prevalence of HCV infection in case series of B-NHL and, when an appropriate control group was available, of the odds ratio of B-NHL associated with HCV infection. A high HCV prevalence in B-NHL was found in southern and eastern Europe, Japan and the southern United States, but not in central and northern Europe, Canada, northern United States, or a few Asian countries. Possible sources of heterogeneity and bias are discussed. The odds ratio of B-NHL for HCV infection was relatively weak, ranging from 2 to 4 in most studies. Thus, even if the observed association were causal, the percentage of cases of B-NHL attributable to HCV infection would be relatively low (10%) also in countries with a high prevalence of HCV infection in the general population, and extremely low in other countries. This may explain apparent inconsistencies between studies. Potential mechanisms of action are also discussed." @default.
- W2079055190 created "2016-06-24" @default.
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- W2079055190 date "2004-01-01" @default.
- W2079055190 modified "2023-10-17" @default.
- W2079055190 title "B-cell non-Hodgkin's lymphoma and hepatitis C virus infection: A systematic review" @default.
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- W2079055190 doi "https://doi.org/10.1002/ijc.20205" @default.
- W2079055190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15185336" @default.
- W2079055190 hasPublicationYear "2004" @default.
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