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- W2079055648 abstract "An alternative scheme for the synthesis of enantiopure α-deuteriated amino acids from a common intermediate is presented. Methyl bis(methylsulfanyl)methylene[2,2-2H2]glycinate was prepared in a mixture of MeOD and D2O with a catalytic amount of Na2CO3 and attached to (2R)-bornane-10,2-sultam. Alkylation of the corresponding enolate provided intermediates which after careful purification were first deprotected on nitrogen and then cleaved from the auxiliary to give deuteriated α-amino acids of very high purity ( > 99% ee and > 98% D). These were directly converted into the corresponding Boc-L-[2-2H]-Ala, -Leu, -Phe and -(O-Bzl)Tyr derivatives, suitable for application in peptide synthesis. Boc-[2,2-2H2]Gly was also prepared." @default.
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- W2079055648 date "1996-01-01" @default.
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- W2079055648 title "Synthesis of enantiopure α-deuteriated Boc-<scp>L</scp>-amino acids" @default.
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- W2079055648 doi "https://doi.org/10.1039/p19960000537" @default.
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