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• W2079055879 abstract "Although the etiopathology of autism spectrum disorder (ASD) is not clear, there is increasing evidence that dysfunction in the immune system affects many children with ASD. Findings of immune dysfunction in ASD include increases in inflammatory cytokines, chemokines, and microglial activity in brain tissue and cerebrospinal fluid, as well as abnormal peripheral immune cell function.Adhesion molecules, such as platelet endothelial adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), P-selectin, and L-selectin, function to facilitate leukocyte transendothelial migration. We assessed concentrations of soluble adhesion molecules, sPECAM-1, sICAM-1, sVCAM-1, sP-selectin, and sL-selectin in the plasma of 49 participants with ASD and 31 typically developing controls of the same age, all of whom were enrolled as part of the Autism Phenome Project. Behavioral assessment, the levels of soluble adhesion molecules, and head circumference were compared in the same subjects.Levels of sPECAM-1 and sP-selectin were significantly reduced in the ASD group compared to typically developing controls (p < .02). Soluble PECAM-1 levels were negatively associated with repetitive behavior and abnormal brain growth in children with ASD (p = .03).Because adhesion molecules modulate the permeability and signaling at the blood-brain barrier as well as leukocyte infiltration into the central nervous system, the current data suggest a role for these molecules in the complex pathophysiology of ASD." @default.
• W2079055879 created "2016-06-24" @default.
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• W2079055879 creator A5091056701 @default.
• W2079055879 date "2012-12-01" @default.
• W2079055879 modified "2023-09-29" @default.
• W2079055879 title "Levels of Soluble Platelet Endothelial Cell Adhesion Molecule-1 and P-Selectin Are Decreased in Children with Autism Spectrum Disorder" @default.
• W2079055879 cites W1512900768 @default.
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• W2079055879 cites W1810066044 @default.
• W2079055879 cites W1960336193 @default.
• W2079055879 cites W1966773673 @default.
• W2079055879 cites W1970841625 @default.
• W2079055879 cites W1972632898 @default.
• W2079055879 cites W1975361661 @default.
• W2079055879 cites W1976451556 @default.
• W2079055879 cites W1976872662 @default.
• W2079055879 cites W1980309199 @default.
• W2079055879 cites W1981593799 @default.
• W2079055879 cites W1982375486 @default.
• W2079055879 cites W1984486655 @default.
• W2079055879 cites W1988372841 @default.
• W2079055879 cites W1990577935 @default.
• W2079055879 cites W1996087940 @default.
• W2079055879 cites W1996593676 @default.
• W2079055879 cites W1997132511 @default.
• W2079055879 cites W1997691550 @default.
• W2079055879 cites W2004265420 @default.
• W2079055879 cites W2004472590 @default.
• W2079055879 cites W2004975856 @default.
• W2079055879 cites W2004995928 @default.
• W2079055879 cites W2006870201 @default.
• W2079055879 cites W2006918320 @default.
• W2079055879 cites W2008026296 @default.
• W2079055879 cites W2008041264 @default.
• W2079055879 cites W2010895019 @default.
• W2079055879 cites W2011993483 @default.
• W2079055879 cites W2014742480 @default.
• W2079055879 cites W2014993261 @default.
• W2079055879 cites W2017918524 @default.
• W2079055879 cites W2018721564 @default.
• W2079055879 cites W2022600227 @default.
• W2079055879 cites W2022654189 @default.
• W2079055879 cites W2023693583 @default.
• W2079055879 cites W2029051321 @default.
• W2079055879 cites W2030658245 @default.
• W2079055879 cites W2034893493 @default.
• W2079055879 cites W2035809865 @default.
• W2079055879 cites W2036955930 @default.
• W2079055879 cites W2042013685 @default.
• W2079055879 cites W2043314631 @default.
• W2079055879 cites W2046371301 @default.
• W2079055879 cites W2049297996 @default.
• W2079055879 cites W2051323365 @default.
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• W2079055879 cites W2056804091 @default.
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• W2079055879 cites W2086858320 @default.
• W2079055879 cites W2099930444 @default.
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• W2079055879 cites W2108398194 @default.
• W2079055879 cites W2108617074 @default.
• W2079055879 cites W2110729320 @default.
• W2079055879 cites W2120691494 @default.
• W2079055879 cites W2121095822 @default.
• W2079055879 cites W2121650847 @default.
• W2079055879 cites W2123848058 @default.
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• W2079055879 cites W2129026301 @default.
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• W2079055879 cites W2137997760 @default.
• W2079055879 cites W2142820307 @default.
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• W2079055879 cites W2167538265 @default.
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• W2079055879 doi "https://doi.org/10.1016/j.biopsych.2012.05.004" @default.
• W2079055879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3496806" @default.
• W2079055879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22717029" @default.
• W2079055879 hasPublicationYear "2012" @default.
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