Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079058439> ?p ?o ?g. }
- W2079058439 endingPage "1548" @default.
- W2079058439 startingPage "1542" @default.
- W2079058439 abstract "The regulation of the classic and alternative bile acid synthetic pathways by key hepatic enzyme activities (microsomal cholesterol 7α-hydroxylase and mitochondrial sterol 27-hydroxylase, respectively) was examined in bile acid depletion and replacement and cholesterol-feeding experiments with rats, guinea pigs, and rabbits. The bile acid pool was depleted by creating a bile fistula (BF) and collecting bile for 2 to 5 days, and it was replaced by intraduodenal infusion of the major biliary bile acids (taurocholic acid [TCA], glycochenodeoxycholic acid [GCDCA], and glycocholic acid [GCA] in the rat, guinea pig, and rabbit, respectively) at rates equivalent to the measured hepatic flux of the bile acids. To study the effects of cholesterol, the animals were fed for 7 days on a basal diet with and without 2% cholesterol. Cholesterol 7α-hydroxylase and sterol 27-hydroxylase activities, measured by isotope incorporation assays, were related to bile acid output and composition and hepatic cholesterol concentrations. Intraduodenal infusion of bile acids increased the output of the tested bile acids, but did not significantly change hepatic cholesterol concentrations and had no effect on sterol 27-hydroxylase activity. Neither bile acid depletion nor replacement affected sterol 27-hydroxylase activity when three different substrates (cholesterol, 5β-cholestane-3α,7α-diol, and 5β-cholestane-3α,7α,12α-triol) were tested. In contrast, feeding 2% cholesterol increased hepatic cholesterol concentrations in rats, guinea pigs, and rabbits threefold, twofold, and eightfold, respectively, and increased hepatic mitochondrial sterol 27-hydroxylase activity (conversion of cholesterol to 27-hydroxycholesterol) in all three animal models. The stimulation and feedback inhibition of cholesterol 7α-hydroxylase activity by bile acid depletion and replacement were observed in all three animal models, whereas the effect of cholesterol feeding was species-dependent (cholesterol 7α-hydroxylase activity increased in the rat, did not change in the guinea pig, and was inhibited in the rabbit). Thus, in contrast to sterol 27-hydroxylase, which was upregulated by cholesterol but not affected by bile acid depletion and replacement in all three animal models, cholesterol 7α-hydroxylase activity was controlled consistently and inversely by the hepatic flux of bile acids, but was species-dependent in its response to a 1-week feeding with 2% cholesterol." @default.
- W2079058439 created "2016-06-24" @default.
- W2079058439 creator A5018794637 @default.
- W2079058439 creator A5031458824 @default.
- W2079058439 creator A5040953121 @default.
- W2079058439 creator A5088748837 @default.
- W2079058439 creator A5089441541 @default.
- W2079058439 creator A5090611425 @default.
- W2079058439 date "1999-12-01" @default.
- W2079058439 modified "2023-09-30" @default.
- W2079058439 title "Comparative regulation of hepatic sterol 27-hydroxylase and cholesterol 7α-hydroxylase activities in the rat, guinea pig, and rabbit: Effects of cholesterol and bile acids" @default.
- W2079058439 cites W1495164395 @default.
- W2079058439 cites W1775749144 @default.
- W2079058439 cites W1819497917 @default.
- W2079058439 cites W1922663375 @default.
- W2079058439 cites W1950608351 @default.
- W2079058439 cites W1962029512 @default.
- W2079058439 cites W1966442116 @default.
- W2079058439 cites W1976794541 @default.
- W2079058439 cites W1989381716 @default.
- W2079058439 cites W1992642803 @default.
- W2079058439 cites W1994538878 @default.
- W2079058439 cites W1995733607 @default.
- W2079058439 cites W1996409802 @default.
- W2079058439 cites W2004423697 @default.
- W2079058439 cites W2007172615 @default.
- W2079058439 cites W2013798704 @default.
- W2079058439 cites W2014083248 @default.
- W2079058439 cites W2019608982 @default.
- W2079058439 cites W2029505705 @default.
- W2079058439 cites W2065915105 @default.
- W2079058439 cites W2087037925 @default.
- W2079058439 cites W2088164016 @default.
- W2079058439 cites W2089230306 @default.
- W2079058439 cites W2092192036 @default.
- W2079058439 cites W2132332858 @default.
- W2079058439 cites W2144397336 @default.
- W2079058439 cites W2154204081 @default.
- W2079058439 cites W2171904028 @default.
- W2079058439 cites W2328429989 @default.
- W2079058439 cites W2342766513 @default.
- W2079058439 cites W2399261648 @default.
- W2079058439 doi "https://doi.org/10.1016/s0026-0495(99)90243-3" @default.
- W2079058439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10599986" @default.
- W2079058439 hasPublicationYear "1999" @default.
- W2079058439 type Work @default.
- W2079058439 sameAs 2079058439 @default.
- W2079058439 citedByCount "35" @default.
- W2079058439 countsByYear W20790584392013 @default.
- W2079058439 countsByYear W20790584392014 @default.
- W2079058439 countsByYear W20790584392018 @default.
- W2079058439 crossrefType "journal-article" @default.
- W2079058439 hasAuthorship W2079058439A5018794637 @default.
- W2079058439 hasAuthorship W2079058439A5031458824 @default.
- W2079058439 hasAuthorship W2079058439A5040953121 @default.
- W2079058439 hasAuthorship W2079058439A5088748837 @default.
- W2079058439 hasAuthorship W2079058439A5089441541 @default.
- W2079058439 hasAuthorship W2079058439A5090611425 @default.
- W2079058439 hasConcept C110459506 @default.
- W2079058439 hasConcept C126322002 @default.
- W2079058439 hasConcept C134018914 @default.
- W2079058439 hasConcept C2775900799 @default.
- W2079058439 hasConcept C2776279336 @default.
- W2079058439 hasConcept C2778163477 @default.
- W2079058439 hasConcept C2778718757 @default.
- W2079058439 hasConcept C2778815084 @default.
- W2079058439 hasConcept C2779399885 @default.
- W2079058439 hasConcept C2780072125 @default.
- W2079058439 hasConcept C2780480987 @default.
- W2079058439 hasConcept C2781089062 @default.
- W2079058439 hasConcept C55493867 @default.
- W2079058439 hasConcept C71924100 @default.
- W2079058439 hasConcept C86803240 @default.
- W2079058439 hasConcept C89673097 @default.
- W2079058439 hasConceptScore W2079058439C110459506 @default.
- W2079058439 hasConceptScore W2079058439C126322002 @default.
- W2079058439 hasConceptScore W2079058439C134018914 @default.
- W2079058439 hasConceptScore W2079058439C2775900799 @default.
- W2079058439 hasConceptScore W2079058439C2776279336 @default.
- W2079058439 hasConceptScore W2079058439C2778163477 @default.
- W2079058439 hasConceptScore W2079058439C2778718757 @default.
- W2079058439 hasConceptScore W2079058439C2778815084 @default.
- W2079058439 hasConceptScore W2079058439C2779399885 @default.
- W2079058439 hasConceptScore W2079058439C2780072125 @default.
- W2079058439 hasConceptScore W2079058439C2780480987 @default.
- W2079058439 hasConceptScore W2079058439C2781089062 @default.
- W2079058439 hasConceptScore W2079058439C55493867 @default.
- W2079058439 hasConceptScore W2079058439C71924100 @default.
- W2079058439 hasConceptScore W2079058439C86803240 @default.
- W2079058439 hasConceptScore W2079058439C89673097 @default.
- W2079058439 hasIssue "12" @default.
- W2079058439 hasLocation W20790584391 @default.
- W2079058439 hasLocation W20790584392 @default.
- W2079058439 hasOpenAccess W2079058439 @default.
- W2079058439 hasPrimaryLocation W20790584391 @default.
- W2079058439 hasRelatedWork W165584051 @default.
- W2079058439 hasRelatedWork W2007234960 @default.
- W2079058439 hasRelatedWork W2046309190 @default.