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• W2079059309 abstract "Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor that serves as an essential regulator of many hormone-induced genes in the vertebrate endocrine system. The apparent absence of a SF-1 ligand prompted speculation that this receptor is regulated by alternative mechanisms involving signal transduction pathways. Here we show that maximal SF-1-mediated transcription and interaction with general nuclear receptor cofactors depends on phosphorylation of a single serine residue (Ser-203) located in a major activation domain (AF-1) of the protein. Moreover, phosphorylation-dependent SF-1 activation is likely mediated by the mitogen-activated protein kinase (MAPK) signaling pathway. We propose that this single modification of SF-1 and the subsequent recruitment of nuclear receptor cofactors couple extracellular signals to steroid and peptide hormone synthesis, thereby maintaining dynamic homeostatic responses in stress and reproduction." @default.
• W2079059309 created "2016-06-24" @default.
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• W2079059309 date "1999-04-01" @default.
• W2079059309 modified "2023-10-13" @default.
• W2079059309 title "Phosphorylation of the Nuclear Receptor SF-1 Modulates Cofactor Recruitment" @default.
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• W2079059309 doi "https://doi.org/10.1016/s1097-2765(00)80480-3" @default.
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