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- W2079062278 abstract "von Hippel-Lindau disease is a hereditary cancer syndrome predisposing carriers to the development of a panel of highly vascularized tumors such as central nervous system and retinal hemangioblastomas, endolymphatic sac tumors, clear-cell renal cell carcinomas, pheochromocytomas and pancreatic neuroendocrine tumors. The disease is the foremost cause of inherited renal cell carcinomas, which is induced by germline mutations of the VHL tumor-suppressor gene also inactivated in most sporadic renal cell carcinomas. VHL appears to be a pivotal gene in the oxygen-sensing pathway, mainly involved in targeting the hypoxia-inducible factors for ubiquitination. This discovery is opening the way for the development of new specific drugs inhibiting hypoxia-inducible factors and/or their downstream targets, possibly representing an attractive treatment not only for von Hippel-Lindau disease but also for sporadic renal cell carcinomas and others cancers." @default.
- W2079062278 created "2016-06-24" @default.
- W2079062278 creator A5034931061 @default.
- W2079062278 date "2003-04-01" @default.
- W2079062278 modified "2023-09-26" @default.
- W2079062278 title "von Hippel-Lindau disease: recent advances and therapeutic perspectives" @default.
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- W2079062278 doi "https://doi.org/10.1586/14737140.3.2.215" @default.
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