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- W2079062376 abstract "Abstract High levels (>1000-fold) of resistance to DDT, permethrin and deltamethrin were detected in Culex quinquefasciatus Say from Saudi Arabia. Biochemical enzyme and metabolic studies indicated that there is evidence for a metabolic basis to both the organochlorine and pyrethroid resistances. Electrophysiological studies indicated that there is no kdr -type mechanism conferring resistance to the pyrethroid lambda-cyhalothrin neurophysiologically, although there is evidence of cross-resistance between DDT and the pyrethroids by bioassays. There was a change in the oxidase system in both the DDT- and permethrin-selected strains and an increase in glutathione transferase activity in the DDT-selected line. Metabolic studies indicated that both oxidases and glutathione transferases are involved with DDT resistance as DDA and DDE were the predominant metabolites after a 5-h in-vitro incubation period. Permethrin resistance is likely to involve an increase in oxidative degradation, but further metabolic studies are needed to confirm this." @default.
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- W2079062376 date "1989-09-01" @default.
- W2079062376 modified "2023-10-16" @default.
- W2079062376 title "Preliminary investigation of the mechanisms of DDT and pyrethroid resistance in <i>Culex quinquefasciatus</i> Say (Diptera: Culicidae) from Saudi Arabia" @default.
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- W2079062376 doi "https://doi.org/10.1017/s0007485300018356" @default.
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