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- W2079063454 abstract "Tissue-mimicking phantoms have previously been developed for assessing the efficacy of therapeutic ultrasound. A new modality of focused ultrasound, histotripsy, relies on the formation of shockwave-induced cavitation to ablate tissue mechanically. The objective of this study was to use a broadband ultrasound method to determine the frequency-dependent attenuation for histotripsy tissue phantoms. An agar tissue phantom was developed with evaporated milk to mimic the acoustomechanical properties of prostate tissue, a key target for histotripsy. The attenuation of this tissue phantom was measured between 2 and 20 MHz using a through-transmission technique with a single pair of PVDF transducers. The power law dependence of the acoustic attenuation spectra was linear with frequency (R2 = 0.98). The attenuation coefficient of the tissue phantom was 0.62 ± 0.02 dB/cm/MHz, which is lower than that reported for ex vivo human prostate at 5 MHz. The broadband measurements techniques utilized provide a straightforward metric for the attenuation spectrum of tissue phantoms developed for shocked insonation regimes." @default.
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- W2079063454 date "2015-04-01" @default.
- W2079063454 modified "2023-09-25" @default.
- W2079063454 title "Broadband attenuation measurements of tissue-mimicking phantoms employed for histotripsy" @default.
- W2079063454 doi "https://doi.org/10.1121/1.4920735" @default.
- W2079063454 hasPublicationYear "2015" @default.
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