FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079063759> ?p ?o ?g. }

• W2079063759 endingPage "25" @default.
• W2079063759 startingPage "18" @default.
• W2079063759 abstract "Tachykinin (TK; including substance P (SP), neurokinin A (NKA) and neurokinin B (NKB))-induced currents (I(TK)s) were studied in freshly isolated rat dorsal root ganglion (DRG) neurons using whole-cell patch clamp recording and repatch techniques. All the three I(TK)s manifested features of fast activating kinetics, such as short latency and fast tau(on) and tau(off), and very slow desensitization. The concentration-response relationships for TKs show: (1). compared with the concentration-response curve for NKA, the curve for NKB shifted upwards, while that for SP shifted downwards; (2). the EC(50) values for NKB-, NKA- and SP-activated currents were very close to each other. The I-V curves for the three TKs were basically linear and arrayed in the order of NKB>NKA>SP; the reversal potentials for the three I(TK)s were all around +15 mV. Replacement of NaCl in the external solution by equimolar N-methyl-D-glucamine (NMDG) attenuated both NKA- and NKB-activated currents markedly, as it was the case with SP-activated current caused by the opening of Na(+) preferring non-selective cation channels observed in our previous work. All the three TKs proved to inhibit coexistent GABA(A) receptor-mediated current (I(GABA)); this effect was removed by intracellular dialysis of GDP-beta-S or H-7. However, these drugs did not block the SP-, NKA- and NKB-activated currents at all, which indicated that I(TK)s were G-protein independent. In short, the responses of rat DRG neurons to SP, NKA and NKB were similar in essence, although the amplitudes of currents induced by the same concentration of the three TKs were different. Taking the results of this study and our previous studies together, we hypothesized that SP, NKA and NKB may induce inward currents through undiscovered channels that are associated with tachykinins receptors (NK1R, NK2R, NK3R, which have already been cloned), but independent of G-protein coupling and remains to be further investigated." @default.
• W2079063759 created "2016-06-24" @default.
• W2079063759 creator A5003059690 @default.
• W2079063759 creator A5036229509 @default.
• W2079063759 creator A5063385583 @default.
• W2079063759 date "2003-11-01" @default.
• W2079063759 modified "2023-10-11" @default.
• W2079063759 title "Similarities of SP-, NKA- and NKB-induced currents in rat dorsal root ganglion neurons" @default.
• W2079063759 cites W1511198581 @default.
• W2079063759 cites W1625740378 @default.
• W2079063759 cites W1659737863 @default.
• W2079063759 cites W1860985526 @default.
• W2079063759 cites W1968946931 @default.
• W2079063759 cites W1979134336 @default.
• W2079063759 cites W1988943183 @default.
• W2079063759 cites W1992296810 @default.
• W2079063759 cites W1994136876 @default.
• W2079063759 cites W2007956587 @default.
• W2079063759 cites W2032413589 @default.
• W2079063759 cites W2056516601 @default.
• W2079063759 cites W2067005918 @default.
• W2079063759 cites W2070568755 @default.
• W2079063759 cites W2079052515 @default.
• W2079063759 cites W2081732610 @default.
• W2079063759 cites W2116447257 @default.
• W2079063759 cites W2123258170 @default.
• W2079063759 cites W2128020612 @default.
• W2079063759 cites W2413216127 @default.
• W2079063759 doi "https://doi.org/10.1016/s0006-8993(03)03451-6" @default.
• W2079063759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14575872" @default.
• W2079063759 hasPublicationYear "2003" @default.
• W2079063759 type Work @default.
• W2079063759 sameAs 2079063759 @default.
• W2079063759 citedByCount "17" @default.
• W2079063759 countsByYear W20790637592012 @default.
• W2079063759 countsByYear W20790637592014 @default.
• W2079063759 countsByYear W20790637592015 @default.
• W2079063759 countsByYear W20790637592017 @default.
• W2079063759 crossrefType "journal-article" @default.
• W2079063759 hasAuthorship W2079063759A5003059690 @default.
• W2079063759 hasAuthorship W2079063759A5036229509 @default.
• W2079063759 hasAuthorship W2079063759A5063385583 @default.
• W2079063759 hasConcept C105702510 @default.
• W2079063759 hasConcept C118303440 @default.
• W2079063759 hasConcept C12554922 @default.
• W2079063759 hasConcept C126322002 @default.
• W2079063759 hasConcept C134018914 @default.
• W2079063759 hasConcept C140530291 @default.
• W2079063759 hasConcept C147944092 @default.
• W2079063759 hasConcept C170493617 @default.
• W2079063759 hasConcept C17077164 @default.
• W2079063759 hasConcept C185592680 @default.
• W2079063759 hasConcept C2776281502 @default.
• W2079063759 hasConcept C2776533618 @default.
• W2079063759 hasConcept C2777056410 @default.
• W2079063759 hasConcept C2780922449 @default.
• W2079063759 hasConcept C2781359426 @default.
• W2079063759 hasConcept C55493867 @default.
• W2079063759 hasConcept C71924100 @default.
• W2079063759 hasConcept C83743174 @default.
• W2079063759 hasConcept C86803240 @default.
• W2079063759 hasConceptScore W2079063759C105702510 @default.
• W2079063759 hasConceptScore W2079063759C118303440 @default.
• W2079063759 hasConceptScore W2079063759C12554922 @default.
• W2079063759 hasConceptScore W2079063759C126322002 @default.
• W2079063759 hasConceptScore W2079063759C134018914 @default.
• W2079063759 hasConceptScore W2079063759C140530291 @default.
• W2079063759 hasConceptScore W2079063759C147944092 @default.
• W2079063759 hasConceptScore W2079063759C170493617 @default.
• W2079063759 hasConceptScore W2079063759C17077164 @default.
• W2079063759 hasConceptScore W2079063759C185592680 @default.
• W2079063759 hasConceptScore W2079063759C2776281502 @default.
• W2079063759 hasConceptScore W2079063759C2776533618 @default.
• W2079063759 hasConceptScore W2079063759C2777056410 @default.
• W2079063759 hasConceptScore W2079063759C2780922449 @default.
• W2079063759 hasConceptScore W2079063759C2781359426 @default.
• W2079063759 hasConceptScore W2079063759C55493867 @default.
• W2079063759 hasConceptScore W2079063759C71924100 @default.
• W2079063759 hasConceptScore W2079063759C83743174 @default.
• W2079063759 hasConceptScore W2079063759C86803240 @default.
• W2079063759 hasIssue "1-2" @default.
• W2079063759 hasLocation W20790637591 @default.
• W2079063759 hasLocation W20790637592 @default.
• W2079063759 hasOpenAccess W2079063759 @default.
• W2079063759 hasPrimaryLocation W20790637591 @default.
• W2079063759 hasRelatedWork W159728948 @default.
• W2079063759 hasRelatedWork W1965333793 @default.
• W2079063759 hasRelatedWork W1978900739 @default.
• W2079063759 hasRelatedWork W1979605070 @default.
• W2079063759 hasRelatedWork W1996021603 @default.
• W2079063759 hasRelatedWork W2042312484 @default.
• W2079063759 hasRelatedWork W2122049503 @default.
• W2079063759 hasRelatedWork W2150393025 @default.
• W2079063759 hasRelatedWork W4256723616 @default.
• W2079063759 hasRelatedWork W48422816 @default.
• W2079063759 hasVolume "991" @default.
• W2079063759 isParatext "false" @default.
• W2079063759 isRetracted "false" @default.

• next