FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079065036> ?p ?o ?g. }

• W2079065036 endingPage "E946" @default.
• W2079065036 startingPage "E936" @default.
• W2079065036 abstract "Trophoblast invasion likely depends on complex cross talk between the fetal and maternal tissues and may involve the modulation of phosphatidylinositol 3-kinase (PI3K)/AKT signaling activity in maternal decidual cells. In this report, we studied implantation in Pten tm1Hwu/tm1Hwu ;Amhr2 tm3(cre)Bhr/+ mice, which lack the PI3K signaling antagonist gene Pten in myometrial and stromal/decidual cells. Primiparous Pten tm1Hwu/tm1Hwu ;Amhr2 tm3(cre)Bhr/+ mice were found to be subfertile because of increased fetal mortality at e11.5. Histopathological analyses revealed a failure of decidual regression in these mice, accompanied by reduced or absent invasion of fetal trophoblast glycogen cells and giant cells, abnormal development of the placental labyrinth, and frequent apparent intrauterine fetal growth restriction. Unexpectedly, the loss of phosphate and tensin homolog deleted on chromosome 10 (PTEN) expression in Pten tm1Hwu/tm1Hwu ;Amhr2 tm3(cre)Bhr/+ decidual cells was not accompanied by a detectable increase in AKT phosphorylation or altered expression or activation of PI3K/AKT downstream effectors such as mammalian target of rapamycin or glycogen synthase kinase-3β. Terminal deoxynucleotidyl transferase-mediated nick end labeling and bromodeoxyuridine incorporation analyses attributed to the lack of decidual regression mainly to decreased apoptosis in Pten tm1Hwu/tm1Hwu ;Amhr2 tm3(cre)Bhr/+ decidual cells, rather than to increased proliferation. Remodeling of the maternal vasculature was delayed in Pten tm1Hwu/tm1Hwu ;Amhr2 tm3(cre)Bhr/+ uteri at e11.5, as evidenced by persistence of vascular smooth muscle and decreased infiltration of uterine natural killer cells. In addition, thickening of the myometrium and disorganization of the muscle fibers were observed before and throughout gestation. Almost all Pten tm1Hwu/tm1Hwu ;Amhr2 tm3(cre)Bhr/+ mice failed to carry a second litter to term, apparently attributable to endometrial hyperplasia and uterine infections. Together, these data demonstrate novel roles of PTEN in the mammalian uterus and its requirement for proper trophoblast invasion and decidual regression." @default.
• W2079065036 created "2016-06-24" @default.
• W2079065036 creator A5000121479 @default.
• W2079065036 creator A5015804810 @default.
• W2079065036 creator A5021621503 @default.
• W2079065036 creator A5037898933 @default.
• W2079065036 creator A5041191383 @default.
• W2079065036 creator A5042904943 @default.
• W2079065036 creator A5083576721 @default.
• W2079065036 date "2010-12-01" @default.
• W2079065036 modified "2023-09-30" @default.
• W2079065036 title "Decidual PTEN expression is required for trophoblast invasion in the mouse" @default.
• W2079065036 cites W1496091321 @default.
• W2079065036 cites W1542767985 @default.
• W2079065036 cites W1983123965 @default.
• W2079065036 cites W1985553251 @default.
• W2079065036 cites W1995211798 @default.
• W2079065036 cites W1996166328 @default.
• W2079065036 cites W2012830778 @default.
• W2079065036 cites W2013736174 @default.
• W2079065036 cites W2020697426 @default.
• W2079065036 cites W2036015212 @default.
• W2079065036 cites W2046575845 @default.
• W2079065036 cites W2060712358 @default.
• W2079065036 cites W2061491996 @default.
• W2079065036 cites W2080965864 @default.
• W2079065036 cites W2086130053 @default.
• W2079065036 cites W2091732735 @default.
• W2079065036 cites W2099166613 @default.
• W2079065036 cites W2120842955 @default.
• W2079065036 cites W2121997180 @default.
• W2079065036 cites W2129887231 @default.
• W2079065036 cites W2131545249 @default.
• W2079065036 cites W2133792952 @default.
• W2079065036 cites W2136170834 @default.
• W2079065036 cites W2139057218 @default.
• W2079065036 cites W2143004704 @default.
• W2079065036 cites W2144010503 @default.
• W2079065036 cites W2154794447 @default.
• W2079065036 cites W2159373438 @default.
• W2079065036 cites W2171389845 @default.
• W2079065036 cites W4238372235 @default.
• W2079065036 doi "https://doi.org/10.1152/ajpendo.00255.2010" @default.
• W2079065036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3006249" @default.
• W2079065036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20858757" @default.
• W2079065036 hasPublicationYear "2010" @default.
• W2079065036 type Work @default.
• W2079065036 sameAs 2079065036 @default.
• W2079065036 citedByCount "28" @default.
• W2079065036 countsByYear W20790650362012 @default.
• W2079065036 countsByYear W20790650362013 @default.
• W2079065036 countsByYear W20790650362014 @default.
• W2079065036 countsByYear W20790650362015 @default.
• W2079065036 countsByYear W20790650362016 @default.
• W2079065036 countsByYear W20790650362017 @default.
• W2079065036 countsByYear W20790650362018 @default.
• W2079065036 countsByYear W20790650362019 @default.
• W2079065036 countsByYear W20790650362020 @default.
• W2079065036 countsByYear W20790650362021 @default.
• W2079065036 countsByYear W20790650362022 @default.
• W2079065036 countsByYear W20790650362023 @default.
• W2079065036 crossrefType "journal-article" @default.
• W2079065036 hasAuthorship W2079065036A5000121479 @default.
• W2079065036 hasAuthorship W2079065036A5015804810 @default.
• W2079065036 hasAuthorship W2079065036A5021621503 @default.
• W2079065036 hasAuthorship W2079065036A5037898933 @default.
• W2079065036 hasAuthorship W2079065036A5041191383 @default.
• W2079065036 hasAuthorship W2079065036A5042904943 @default.
• W2079065036 hasAuthorship W2079065036A5083576721 @default.
• W2079065036 hasBestOaLocation W20790650362 @default.
• W2079065036 hasConcept C126322002 @default.
• W2079065036 hasConcept C134018914 @default.
• W2079065036 hasConcept C16930146 @default.
• W2079065036 hasConcept C172680121 @default.
• W2079065036 hasConcept C2776953305 @default.
• W2079065036 hasConcept C2777495146 @default.
• W2079065036 hasConcept C2777609662 @default.
• W2079065036 hasConcept C2778164554 @default.
• W2079065036 hasConcept C2779066055 @default.
• W2079065036 hasConcept C2779234561 @default.
• W2079065036 hasConcept C2779549131 @default.
• W2079065036 hasConcept C2780197806 @default.
• W2079065036 hasConcept C2781107390 @default.
• W2079065036 hasConcept C502942594 @default.
• W2079065036 hasConcept C54355233 @default.
• W2079065036 hasConcept C62478195 @default.
• W2079065036 hasConcept C71924100 @default.
• W2079065036 hasConcept C75217442 @default.
• W2079065036 hasConcept C86554907 @default.
• W2079065036 hasConcept C86803240 @default.
• W2079065036 hasConcept C95444343 @default.
• W2079065036 hasConceptScore W2079065036C126322002 @default.
• W2079065036 hasConceptScore W2079065036C134018914 @default.
• W2079065036 hasConceptScore W2079065036C16930146 @default.
• W2079065036 hasConceptScore W2079065036C172680121 @default.
• W2079065036 hasConceptScore W2079065036C2776953305 @default.
• W2079065036 hasConceptScore W2079065036C2777495146 @default.
• W2079065036 hasConceptScore W2079065036C2777609662 @default.

• next