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• W2079068024 abstract "This study was conducted to examine the mechanism(s) of synergistic interaction of histamine- and adrenaline-mediated human platelet aggregation. We found that platelet aggregation mediated by subthreshold concentrations of histamine (1–4 μm) plus adrenaline (0.5–2 μm) is inhibited by both an α2-adrenoceptor blocker (yohimbine) and a histamine (H1) receptor antagonist (diphenhydramine). In examining the role of the downstream signalling pathway, we found that such an interaction is inhibited by the calcium channel blockers verapamil and diltiazem. However, platelet aggregation by adrenaline plus histamine was inhibited by very low concentrations of the phospholipase C (PLC) inhibitor, U73122 (IC50= 1.2 μm), the MEK inhibitor, PD98059 (IC50= 1.1 μm) and the cyclo-oxygenase (COX) inhibitor, indomethacin (IC50= 7 μm). However the inhibition of receptor tyrosine kinase, protein kinase C and phosphatidylinositol 3-kinase by genistien, chelerythrine and wortmannin, respectively, had no significant effect on aggregation. Similarly the nitric oxide donor (SNAP) had no effect on this synergism. These data suggest that the synergistic effect of histamine and adrenaline during human platelet aggregation is receptor mediated and involves activation of PLC, COX and MAP kinase signalling pathways." @default.
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• W2079068024 date "2000-11-01" @default.
• W2079068024 modified "2023-10-17" @default.
• W2079068024 title "Synergistic interaction of adrenaline and histamine in human platelet aggregation is mediated through activation of phospholipase, map kinase and cyclo-oxygenase pathways" @default.
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• W2079068024 doi "https://doi.org/10.1006/phrs.2000.0721" @default.
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