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- W2079069049 abstract "Abstract In an effort to evaluate some laboratory procedures and therapeutic modalities commonly employed in patients suspected of suffering from disseminated intravascular coagulation (DIC), such a state was induced in dogs by means of intravascular infusion of Thrombin. The laboratory procedures included the protamine sulfate and ethanol gelation tests, platelet count, prothrombin time, partial thromboplastin time, thrombin time, fibrinogen concentration and euglobulin lysis time. Heparin, e-aminocaproic acid, and a combination of both drugs represented the therapeutic measures used. Of the laboratory tests mentioned, the protamine sulfate test was both sensitive and specific and was therefore considered the most useful procedure in recognizing intravascular fibrin formation. As regards the other tests, a marked drop in the fibrinogen level and in the platelet count were the most consistent findings. The thrombin time tended to be markedly prolonged, whereas the euglobulin lysis time was found to undergo the least change. The effect of treatment was gauged by the extent to which the drugs employed appeared to minimize the change in results of the various tests caused by thrombin infusion. The combination of Heparin with e-aminocaproic acid seemed to be most effective in this respect, particularly with regard to the platelet count and the fibrinogen level. The Reptilase time which replaced the thrombin time in the testing of Heparin-containing blood specimens was very useful in monitoring the effect of Heparin in the prevention or treatment of thrombin-induced changes in the laboratory tests." @default.
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- W2079069049 date "1975-03-01" @default.
- W2079069049 modified "2023-09-26" @default.
- W2079069049 title "Experimental disseminated intravascular coagulation effect of heparin and e-aminocaproic acid on test of hemostatic function" @default.
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- W2079069049 doi "https://doi.org/10.1016/0049-3848(75)90071-7" @default.
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