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- W2079069618 abstract "Abstract Alone, the 5HT uptake inhibitors chlorimipramine (20 mg/kg s.c.) or femoxetine (20 mg/kg s.c.) had no effect on the motility of mice kept in a familiar cage. Similarly, pretreatment with clorgyline (a selective inhibitor of MAO-A), or l -deprenyl (a selective inhibitor of MAO-B) followed by administration of either of the 5HT pump blockers, had no effect on motility. However, pretreatment with a combination of clorgyline plus deprenyl, followed by either chlorimipramine or femoxetine, resulted in strong hypermotility. These results indicate that hypermotility seen after administration of a 5HT pump blocker to mice pretreated with a MAO inhibitor, depends on inhibition of both MAO-A and MAO-B, and is due to a high extraneuronal concentration of 5HT." @default.
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- W2079069618 date "1977-07-01" @default.
- W2079069618 modified "2023-09-27" @default.
- W2079069618 title "Inhibition of both MAO-A and MAO-B required for the production of hypermotility in mice with the 5HT uptake inhibitors chlorimipramine and femoxetine" @default.
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- W2079069618 doi "https://doi.org/10.1016/0028-3908(77)90005-3" @default.
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