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• W2079069682 abstract "Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression. Originally, PML was observed in patients with advanced HIV infection, lymphoproliferative disorders and transplant recipients. However, the widespread use of HIV antiretroviral drugs and the new selective immunomodulatory and immunosuppressive medications, such as Rituximab and Natalizumab, has recently modified the epidemiology, clinical presentation and prognosis of PML. Herein, we discuss the new concepts on PML, emphasizing the recent modification in the epidemiology; the impact of new immunomodulatory treatments in the disease, PML-IRIS (Immune reconstitution inflammatory síndrome), new treatment strategies and other JCV related CNS diseases." @default.
• W2079069682 created "2016-06-24" @default.
• W2079069682 creator A5020325459 @default.
• W2079069682 date "2013-09-01" @default.
• W2079069682 modified "2023-10-16" @default.
• W2079069682 title "Progressive multifocal leukoencephalopathy: new concepts" @default.
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• W2079069682 doi "https://doi.org/10.1590/0004-282x20130154" @default.
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