Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079069922> ?p ?o ?g. }
- W2079069922 endingPage "e115041" @default.
- W2079069922 startingPage "e115041" @default.
- W2079069922 abstract "The purpose of this study is to investigate the anti-angiogenic activities of NSK-01105, a novel sorafenib derivative, in in vitro, ex vivo and in vivo models, and explore the potential mechanisms. NSK-01105 significantly inhibited vascular endothelial growth factor (VEGF)-induced migration and tube formation of human umbilical vein endothelial cells at non-cytotoxic concentrations as shown by wound-healing, transwell migration and endothelial cell tube formation assays, respectively. Cell viability and invasion of LNCaP and PC-3 cells were significantly inhibited by cytotoxicity assay and matrigel invasion assay. Furthermore, NSK-01105 also inhibited ex vivo angiogenesis in matrigel plug assay. Western blot analysis showed that NSK-01105 down-regulated VEGF-induced phosphorylation of VEGF receptor 2 (VEGFR2) and the activation of epidermal growth factor receptor (EGFR). Tumor volumes were significantly reduced by NSK-01105 at 60 mg/kg/day in both xenograft models. Immunohistochemical staining demonstrated a close association between inhibition of tumor growth and neovascularization. Collectively, our results suggest a role of NSK-01105 in treatment for human prostate tumors, and one of the potential mechanisms may be attributed to anti-angiogenic activities." @default.
- W2079069922 created "2016-06-24" @default.
- W2079069922 creator A5024318270 @default.
- W2079069922 creator A5025919070 @default.
- W2079069922 creator A5033251954 @default.
- W2079069922 creator A5040915613 @default.
- W2079069922 creator A5042048777 @default.
- W2079069922 creator A5048956159 @default.
- W2079069922 creator A5066906722 @default.
- W2079069922 creator A5068860723 @default.
- W2079069922 date "2014-12-31" @default.
- W2079069922 modified "2023-10-18" @default.
- W2079069922 title "NSK-01105, a Novel Sorafenib Derivative, Inhibits Human Prostate Tumor Growth via Suppression of VEGFR2/EGFR-Mediated Angiogenesis" @default.
- W2079069922 cites W145904191 @default.
- W2079069922 cites W1569333935 @default.
- W2079069922 cites W1868766650 @default.
- W2079069922 cites W1868957569 @default.
- W2079069922 cites W1964444307 @default.
- W2079069922 cites W1980302506 @default.
- W2079069922 cites W1982114820 @default.
- W2079069922 cites W1982733159 @default.
- W2079069922 cites W1994327821 @default.
- W2079069922 cites W1994928998 @default.
- W2079069922 cites W2000292756 @default.
- W2079069922 cites W2006736903 @default.
- W2079069922 cites W2028317042 @default.
- W2079069922 cites W2033711687 @default.
- W2079069922 cites W2044776722 @default.
- W2079069922 cites W2046507292 @default.
- W2079069922 cites W2050305662 @default.
- W2079069922 cites W2062739811 @default.
- W2079069922 cites W2063670001 @default.
- W2079069922 cites W2072141511 @default.
- W2079069922 cites W2077701186 @default.
- W2079069922 cites W2083400761 @default.
- W2079069922 cites W2083446428 @default.
- W2079069922 cites W2099999103 @default.
- W2079069922 cites W2100304447 @default.
- W2079069922 cites W2102140960 @default.
- W2079069922 cites W2112099875 @default.
- W2079069922 cites W2114258883 @default.
- W2079069922 cites W2118559000 @default.
- W2079069922 cites W2119402609 @default.
- W2079069922 cites W2120468822 @default.
- W2079069922 cites W2124732705 @default.
- W2079069922 cites W2126565162 @default.
- W2079069922 cites W2128465480 @default.
- W2079069922 cites W2128982430 @default.
- W2079069922 cites W2130239587 @default.
- W2079069922 cites W2134755472 @default.
- W2079069922 cites W2140765540 @default.
- W2079069922 cites W2145189030 @default.
- W2079069922 cites W2154493372 @default.
- W2079069922 cites W2163116430 @default.
- W2079069922 cites W2189117181 @default.
- W2079069922 cites W2314878275 @default.
- W2079069922 doi "https://doi.org/10.1371/journal.pone.0115041" @default.
- W2079069922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4281216" @default.
- W2079069922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25551444" @default.
- W2079069922 hasPublicationYear "2014" @default.
- W2079069922 type Work @default.
- W2079069922 sameAs 2079069922 @default.
- W2079069922 citedByCount "12" @default.
- W2079069922 countsByYear W20790699222015 @default.
- W2079069922 countsByYear W20790699222016 @default.
- W2079069922 countsByYear W20790699222017 @default.
- W2079069922 countsByYear W20790699222018 @default.
- W2079069922 countsByYear W20790699222019 @default.
- W2079069922 countsByYear W20790699222020 @default.
- W2079069922 countsByYear W20790699222021 @default.
- W2079069922 crossrefType "journal-article" @default.
- W2079069922 hasAuthorship W2079069922A5024318270 @default.
- W2079069922 hasAuthorship W2079069922A5025919070 @default.
- W2079069922 hasAuthorship W2079069922A5033251954 @default.
- W2079069922 hasAuthorship W2079069922A5040915613 @default.
- W2079069922 hasAuthorship W2079069922A5042048777 @default.
- W2079069922 hasAuthorship W2079069922A5048956159 @default.
- W2079069922 hasAuthorship W2079069922A5066906722 @default.
- W2079069922 hasAuthorship W2079069922A5068860723 @default.
- W2079069922 hasBestOaLocation W20790699221 @default.
- W2079069922 hasConcept C121608353 @default.
- W2079069922 hasConcept C146285616 @default.
- W2079069922 hasConcept C14858245 @default.
- W2079069922 hasConcept C1491633281 @default.
- W2079069922 hasConcept C150903083 @default.
- W2079069922 hasConcept C167734588 @default.
- W2079069922 hasConcept C170493617 @default.
- W2079069922 hasConcept C185592680 @default.
- W2079069922 hasConcept C202751555 @default.
- W2079069922 hasConcept C207001950 @default.
- W2079069922 hasConcept C26291073 @default.
- W2079069922 hasConcept C2777025900 @default.
- W2079069922 hasConcept C2777411675 @default.
- W2079069922 hasConcept C2777834122 @default.
- W2079069922 hasConcept C2778019345 @default.
- W2079069922 hasConcept C2778271429 @default.
- W2079069922 hasConcept C2778608917 @default.
- W2079069922 hasConcept C2778695046 @default.