Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079071483> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2079071483 endingPage "3159" @default.
- W2079071483 startingPage "3157" @default.
- W2079071483 abstract "Atherosclerotic cardiovascular diseases are the leading cause of death in developed and developing countries. HDL-raising therapeutic modalities (such as cholesterol ester transferase protein (CETP) inhibitors) are being developed to combat these diseases. However, recent setback of two CETP inhibitors (Torcetrapib and Dalcetrapib) has highlighted the importance of measuring qualitative functionality of HDL particles, rather than focusing quantitatively on HDL cholesterol serum concentrations. It has been known that, HDL from patients with coronary artery disease (CAD) (i.e., HDL(CAD)) limits the anti-inflammatory and endothelial repair properties of normal HDL, due to the activation of lectin-like oxidized LDL receptor-1 (LOX-1), thereby causing failure in endothelial nitric oxide (NO) production. A more recent study (Immunity 2013; 38: 754-768) also demonstrates that HDL from patients with chronic kidney dysfunction (CKD) (i.e., HDL(CKD)), unlike its healthy counterpart (i.e., HDL(Healthy)), promotes superoxide production, reduces NO bioavailability and raises blood pressure via toll-like receptor-2 (TLR-2) activation. This study provides novel insights into understanding why HDL-raising agents failed to demonstrate beneficial effects on cardiovascular mortality in large clinical trials and why CKD accelerates the development of atherosclerosis in CAD patients. Further research is warranted to elucidate whether HDL(CKD) and HDL(CAD) participate in other cellular processes in atherosclerosis, such as foam cell formation, the proliferation and migration of smooth muscle cells, and most importantly, plaque destabilization." @default.
- W2079071483 created "2016-06-24" @default.
- W2079071483 creator A5009067006 @default.
- W2079071483 creator A5032138738 @default.
- W2079071483 creator A5069805999 @default.
- W2079071483 date "2013-10-01" @default.
- W2079071483 modified "2023-10-16" @default.
- W2079071483 title "HDL cholesterol in cardiovascular diseases: The good, the bad, and the ugly?" @default.
- W2079071483 cites W1566221130 @default.
- W2079071483 cites W1569311543 @default.
- W2079071483 cites W1972104638 @default.
- W2079071483 cites W1978369960 @default.
- W2079071483 cites W1997557110 @default.
- W2079071483 cites W2011478596 @default.
- W2079071483 cites W2017302584 @default.
- W2079071483 cites W2017754180 @default.
- W2079071483 cites W2017903297 @default.
- W2079071483 cites W2060034277 @default.
- W2079071483 cites W2074858589 @default.
- W2079071483 cites W2076391176 @default.
- W2079071483 cites W2139292309 @default.
- W2079071483 cites W2152415811 @default.
- W2079071483 cites W2157157967 @default.
- W2079071483 cites W2335732739 @default.
- W2079071483 doi "https://doi.org/10.1016/j.ijcard.2013.07.210" @default.
- W2079071483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23962777" @default.
- W2079071483 hasPublicationYear "2013" @default.
- W2079071483 type Work @default.
- W2079071483 sameAs 2079071483 @default.
- W2079071483 citedByCount "21" @default.
- W2079071483 countsByYear W20790714832014 @default.
- W2079071483 countsByYear W20790714832016 @default.
- W2079071483 countsByYear W20790714832017 @default.
- W2079071483 countsByYear W20790714832018 @default.
- W2079071483 countsByYear W20790714832019 @default.
- W2079071483 countsByYear W20790714832020 @default.
- W2079071483 countsByYear W20790714832021 @default.
- W2079071483 countsByYear W20790714832023 @default.
- W2079071483 crossrefType "journal-article" @default.
- W2079071483 hasAuthorship W2079071483A5009067006 @default.
- W2079071483 hasAuthorship W2079071483A5032138738 @default.
- W2079071483 hasAuthorship W2079071483A5069805999 @default.
- W2079071483 hasConcept C126322002 @default.
- W2079071483 hasConcept C134018914 @default.
- W2079071483 hasConcept C164705383 @default.
- W2079071483 hasConcept C2777895019 @default.
- W2079071483 hasConcept C2778163477 @default.
- W2079071483 hasConcept C2778213512 @default.
- W2079071483 hasConcept C2778653478 @default.
- W2079071483 hasConcept C2780072125 @default.
- W2079071483 hasConcept C2780972559 @default.
- W2079071483 hasConcept C45505151 @default.
- W2079071483 hasConcept C519581460 @default.
- W2079071483 hasConcept C71924100 @default.
- W2079071483 hasConceptScore W2079071483C126322002 @default.
- W2079071483 hasConceptScore W2079071483C134018914 @default.
- W2079071483 hasConceptScore W2079071483C164705383 @default.
- W2079071483 hasConceptScore W2079071483C2777895019 @default.
- W2079071483 hasConceptScore W2079071483C2778163477 @default.
- W2079071483 hasConceptScore W2079071483C2778213512 @default.
- W2079071483 hasConceptScore W2079071483C2778653478 @default.
- W2079071483 hasConceptScore W2079071483C2780072125 @default.
- W2079071483 hasConceptScore W2079071483C2780972559 @default.
- W2079071483 hasConceptScore W2079071483C45505151 @default.
- W2079071483 hasConceptScore W2079071483C519581460 @default.
- W2079071483 hasConceptScore W2079071483C71924100 @default.
- W2079071483 hasFunder F4320321001 @default.
- W2079071483 hasIssue "4" @default.
- W2079071483 hasLocation W20790714831 @default.
- W2079071483 hasLocation W20790714832 @default.
- W2079071483 hasOpenAccess W2079071483 @default.
- W2079071483 hasPrimaryLocation W20790714831 @default.
- W2079071483 hasRelatedWork W1491900378 @default.
- W2079071483 hasRelatedWork W2028375480 @default.
- W2079071483 hasRelatedWork W2035331946 @default.
- W2079071483 hasRelatedWork W2107804609 @default.
- W2079071483 hasRelatedWork W2112046710 @default.
- W2079071483 hasRelatedWork W2118738696 @default.
- W2079071483 hasRelatedWork W2166097078 @default.
- W2079071483 hasRelatedWork W2309126100 @default.
- W2079071483 hasRelatedWork W4244653511 @default.
- W2079071483 hasRelatedWork W2572400005 @default.
- W2079071483 hasVolume "168" @default.
- W2079071483 isParatext "false" @default.
- W2079071483 isRetracted "false" @default.
- W2079071483 magId "2079071483" @default.
- W2079071483 workType "article" @default.