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- W2079072407 abstract "Purpose: Contour propagation reduces effects of physician variability as well as the workload associated with manual contouring. However, its effect on PET based treatment response assessment is unknown. We compared the effects of manual contouring and deformable-registration-based contour propagation on treatment response assessment. Method and Materials: Ten adult patients with various tumors underwent one pre-treatment and two follow-up whole body PET/CT scans [18F]FLT, a cellular proliferation marker. Most tumors were in proximity of highly deformable tissues, such as abdomen and lung. Manual contours of tumors were drawn on PET images by a nuclear medicine physician. Pre-treatment contours were chosen as the reference. Pre-treatment CT was deformably registered to follow-up CT using the fast-free-form deformable registration. Deformation fields resulting from the registration were used to propagate the reference to follow-up contours. A Matching index () was used to quantify the overlapped volume of manual and propagated contours. Treatment responses using manual and propagated contours were then evaluated by calculating the relative change of SUVmean (ΔSUVmean) and SUVmax (ΔSUVmax) between pre-treatment and follow-up scans. Results: The average matching index was 35% and ranged from 5% to 70%. This mismatch led to differences in treatment response assessment between manual contouring and contour propagation. The average difference in ΔSUVmean was 15% and ranged from 5% to 35%. While ΔSUVmax had similar average difference and range, treatment responses using ΔSUVmax of four patients were found to be insensitive to contouring methods. However, differences in ΔSUVmean always occurred. Conclusion: The study showed that the treatment response was quite sensitive to different contouring methods. Fast-free-form deformable registration of tumor anatomy was insufficient to capture the change of tumor. Assistance of manual contour adjustment or other deformable registration is needed to fully capture the organ deformation on highly deformable tissues." @default.
- W2079072407 created "2016-06-24" @default.
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- W2079072407 date "2010-06-01" @default.
- W2079072407 modified "2023-09-26" @default.
- W2079072407 title "SU-GG-J-155: Impact of Deformable-Registration-Based Contour Propagation on PET Based Treatment Response Assessment" @default.
- W2079072407 doi "https://doi.org/10.1118/1.3468379" @default.
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