FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079072410> ?p ?o ?g. }

• W2079072410 endingPage "704" @default.
• W2079072410 startingPage "697" @default.
• W2079072410 abstract "The anatomic distribution of N-methyl-D-aspartate receptors was investigated in the squirrel monkey brain using quantitative autoradiography with [125I]MK-801 as the radioligand. A heterogeneous distribution of [125I]MK-801 binding sites was observed, with the most intense expression in the outer cortex, hippocampus, olfactory tubercle, caudate and putamen. High levels were also observed in the thalamus, nucleus accumbens and inner cortex, with moderate levels in the claustrum. Relatively low expression levels were detected in the subthalamic nucleus with no apparent binding in the globus pallidus and the substantia nigra. Characterization of striatal [125I]MK-801 binding yielded a B(max) of 63.5 fmol/mg tissue and K(d) of 0.53 nM in the caudate, with similar values for the putamen. Experiments were subsequently performed to compare striatal [125I]MK-801 binding in the following four experimental groups: (i) control animals injected with saline; (ii) monkeys treated with levodopa; (iii) animals rendered parkinsonian after exposure to the neurotoxicant 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine; and (iv) dyskinetic monkeys treated with both 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and levodopa. No changes were observed in 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-lesioned animals compared with the saline control group. However, administration of levodopa to either unlesioned or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys resulted in a significant decrease in [125I]MK-801 binding in both the caudate and putamen. The data indicate that levodopa exerts a modulatory effect on the striatal glutamatergic system and suggest that a down-regulation of N-methyl-D-aspartate receptors by levodopa, combined with a deficiency in nigrostriatal dopamine function, may play a role in the development of levodopa induced dyskinesias." @default.
• W2079072410 created "2016-06-24" @default.
• W2079072410 creator A5022945644 @default.
• W2079072410 creator A5035849217 @default.
• W2079072410 creator A5066471162 @default.
• W2079072410 creator A5090663988 @default.
• W2079072410 date "2000-08-01" @default.
• W2079072410 modified "2023-09-26" @default.
• W2079072410 title "Autoradiographic analysis of N-methyl-d-aspartate receptor binding in monkey brain: effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Levodopa treatment" @default.
• W2079072410 cites W1569799839 @default.
• W2079072410 cites W1600539804 @default.
• W2079072410 cites W175006040 @default.
• W2079072410 cites W1849626795 @default.
• W2079072410 cites W1884157132 @default.
• W2079072410 cites W1967015115 @default.
• W2079072410 cites W1969501292 @default.
• W2079072410 cites W1970853027 @default.
• W2079072410 cites W1979603689 @default.
• W2079072410 cites W1985420205 @default.
• W2079072410 cites W1987351877 @default.
• W2079072410 cites W1996046462 @default.
• W2079072410 cites W2003179182 @default.
• W2079072410 cites W2007037518 @default.
• W2079072410 cites W2014004733 @default.
• W2079072410 cites W2016232178 @default.
• W2079072410 cites W2018739299 @default.
• W2079072410 cites W2021267186 @default.
• W2079072410 cites W2026847157 @default.
• W2079072410 cites W2030636745 @default.
• W2079072410 cites W2031326543 @default.
• W2079072410 cites W2035821290 @default.
• W2079072410 cites W2038716909 @default.
• W2079072410 cites W2039279856 @default.
• W2079072410 cites W2045442724 @default.
• W2079072410 cites W2055017748 @default.
• W2079072410 cites W2055654059 @default.
• W2079072410 cites W2057061036 @default.
• W2079072410 cites W2058897561 @default.
• W2079072410 cites W2062524799 @default.
• W2079072410 cites W2072406125 @default.
• W2079072410 cites W2077643386 @default.
• W2079072410 cites W2087203225 @default.
• W2079072410 cites W2103489006 @default.
• W2079072410 cites W2106631077 @default.
• W2079072410 cites W2112648950 @default.
• W2079072410 cites W2113826471 @default.
• W2079072410 cites W2132008514 @default.
• W2079072410 cites W2138289874 @default.
• W2079072410 cites W2154974608 @default.
• W2079072410 cites W4294359531 @default.
• W2079072410 doi "https://doi.org/10.1016/s0306-4522(00)00235-9" @default.
• W2079072410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10974432" @default.
• W2079072410 hasPublicationYear "2000" @default.
• W2079072410 type Work @default.
• W2079072410 sameAs 2079072410 @default.
• W2079072410 citedByCount "15" @default.
• W2079072410 countsByYear W20790724102013 @default.
• W2079072410 countsByYear W20790724102014 @default.
• W2079072410 countsByYear W20790724102015 @default.
• W2079072410 countsByYear W20790724102016 @default.
• W2079072410 countsByYear W20790724102021 @default.
• W2079072410 crossrefType "journal-article" @default.
• W2079072410 hasAuthorship W2079072410A5022945644 @default.
• W2079072410 hasAuthorship W2079072410A5035849217 @default.
• W2079072410 hasAuthorship W2079072410A5066471162 @default.
• W2079072410 hasAuthorship W2079072410A5090663988 @default.
• W2079072410 hasConcept C110726550 @default.
• W2079072410 hasConcept C126322002 @default.
• W2079072410 hasConcept C134018914 @default.
• W2079072410 hasConcept C137183658 @default.
• W2079072410 hasConcept C185592680 @default.
• W2079072410 hasConcept C2776552330 @default.
• W2079072410 hasConcept C2778187257 @default.
• W2079072410 hasConcept C2779714222 @default.
• W2079072410 hasConcept C2780062018 @default.
• W2079072410 hasConcept C2780278869 @default.
• W2079072410 hasConcept C2780938664 @default.
• W2079072410 hasConcept C2781423529 @default.
• W2079072410 hasConcept C513476851 @default.
• W2079072410 hasConcept C529278444 @default.
• W2079072410 hasConcept C71924100 @default.
• W2079072410 hasConcept C86803240 @default.
• W2079072410 hasConceptScore W2079072410C110726550 @default.
• W2079072410 hasConceptScore W2079072410C126322002 @default.
• W2079072410 hasConceptScore W2079072410C134018914 @default.
• W2079072410 hasConceptScore W2079072410C137183658 @default.
• W2079072410 hasConceptScore W2079072410C185592680 @default.
• W2079072410 hasConceptScore W2079072410C2776552330 @default.
• W2079072410 hasConceptScore W2079072410C2778187257 @default.
• W2079072410 hasConceptScore W2079072410C2779714222 @default.
• W2079072410 hasConceptScore W2079072410C2780062018 @default.
• W2079072410 hasConceptScore W2079072410C2780278869 @default.
• W2079072410 hasConceptScore W2079072410C2780938664 @default.
• W2079072410 hasConceptScore W2079072410C2781423529 @default.
• W2079072410 hasConceptScore W2079072410C513476851 @default.
• W2079072410 hasConceptScore W2079072410C529278444 @default.
• W2079072410 hasConceptScore W2079072410C71924100 @default.
• W2079072410 hasConceptScore W2079072410C86803240 @default.

• next