Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079073162> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2079073162 endingPage "626" @default.
- W2079073162 startingPage "622" @default.
- W2079073162 abstract "The effects of pre- (30 min before challenge) and post-treatment (5 min after challenge) of L-arginine (840 mg kg(-1)) were tested on picrotoxin-induced increase in ammonia concentrations in brain regions (cerebral cortex, brain stem and cerebellum) and the accompanying convulsive responses in adult male rats. The effect of pre- and post-treatment of L-arginine was tested on the action of diazepam against picrotoxin-induced convulsions. Picrotoxin-induced increase in ammonia concentrations in the brain regions was reverted partially by L-arginine pre-treatment. However, L-arginine pre-treatment failed to inhibit convulsions independently and concurrently with diazepam. On the other hand, L-arginine post-treatment reverted ammonia to control level in all brain regions. A partial but significant inhibition of convulsions was found in these animals. The effect produced concurrently by L-arginine and diazepam post-treatment was much greater than that produced by these agents independently. These results suggest that brain ammonia has a partial but significant participation in the convulsant action of picrotoxin. L-arginine has produced a partial protection of picrotoxin-induced convulsions by reverting brain ammonia to control level. The data further suggest that the duration of action of L-arginine is considerably short and that L-arginine has an additive anticonvulsant action with diazepam." @default.
- W2079073162 created "2016-06-24" @default.
- W2079073162 creator A5037957800 @default.
- W2079073162 creator A5070791620 @default.
- W2079073162 date "2001-09-01" @default.
- W2079073162 modified "2023-09-22" @default.
- W2079073162 title "Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam" @default.
- W2079073162 cites W1412257551 @default.
- W2079073162 cites W1970160799 @default.
- W2079073162 cites W1971524376 @default.
- W2079073162 cites W1982153946 @default.
- W2079073162 cites W1983741484 @default.
- W2079073162 cites W1987481833 @default.
- W2079073162 cites W1994288348 @default.
- W2079073162 cites W1995501216 @default.
- W2079073162 cites W2005760338 @default.
- W2079073162 cites W2040013286 @default.
- W2079073162 cites W2049224437 @default.
- W2079073162 cites W2062083637 @default.
- W2079073162 cites W2064395950 @default.
- W2079073162 cites W2072596418 @default.
- W2079073162 cites W2073081959 @default.
- W2079073162 cites W2079439539 @default.
- W2079073162 cites W2083702253 @default.
- W2079073162 cites W2116713648 @default.
- W2079073162 cites W2126159344 @default.
- W2079073162 cites W2144574205 @default.
- W2079073162 cites W71370111 @default.
- W2079073162 doi "https://doi.org/10.1179/016164101101198901" @default.
- W2079073162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11547931" @default.
- W2079073162 hasPublicationYear "2001" @default.
- W2079073162 type Work @default.
- W2079073162 sameAs 2079073162 @default.
- W2079073162 citedByCount "2" @default.
- W2079073162 countsByYear W20790731622015 @default.
- W2079073162 crossrefType "journal-article" @default.
- W2079073162 hasAuthorship W2079073162A5037957800 @default.
- W2079073162 hasAuthorship W2079073162A5070791620 @default.
- W2079073162 hasConcept C126322002 @default.
- W2079073162 hasConcept C134018914 @default.
- W2079073162 hasConcept C15744967 @default.
- W2079073162 hasConcept C168258287 @default.
- W2079073162 hasConcept C169760540 @default.
- W2079073162 hasConcept C170493617 @default.
- W2079073162 hasConcept C185592680 @default.
- W2079073162 hasConcept C2775858608 @default.
- W2079073162 hasConcept C2776175493 @default.
- W2079073162 hasConcept C2777010014 @default.
- W2079073162 hasConcept C2777468819 @default.
- W2079073162 hasConcept C2778186239 @default.
- W2079073162 hasConcept C2778900099 @default.
- W2079073162 hasConcept C2779324764 @default.
- W2079073162 hasConcept C42219234 @default.
- W2079073162 hasConcept C515207424 @default.
- W2079073162 hasConcept C55493867 @default.
- W2079073162 hasConcept C71924100 @default.
- W2079073162 hasConcept C98274493 @default.
- W2079073162 hasConceptScore W2079073162C126322002 @default.
- W2079073162 hasConceptScore W2079073162C134018914 @default.
- W2079073162 hasConceptScore W2079073162C15744967 @default.
- W2079073162 hasConceptScore W2079073162C168258287 @default.
- W2079073162 hasConceptScore W2079073162C169760540 @default.
- W2079073162 hasConceptScore W2079073162C170493617 @default.
- W2079073162 hasConceptScore W2079073162C185592680 @default.
- W2079073162 hasConceptScore W2079073162C2775858608 @default.
- W2079073162 hasConceptScore W2079073162C2776175493 @default.
- W2079073162 hasConceptScore W2079073162C2777010014 @default.
- W2079073162 hasConceptScore W2079073162C2777468819 @default.
- W2079073162 hasConceptScore W2079073162C2778186239 @default.
- W2079073162 hasConceptScore W2079073162C2778900099 @default.
- W2079073162 hasConceptScore W2079073162C2779324764 @default.
- W2079073162 hasConceptScore W2079073162C42219234 @default.
- W2079073162 hasConceptScore W2079073162C515207424 @default.
- W2079073162 hasConceptScore W2079073162C55493867 @default.
- W2079073162 hasConceptScore W2079073162C71924100 @default.
- W2079073162 hasConceptScore W2079073162C98274493 @default.
- W2079073162 hasIssue "6" @default.
- W2079073162 hasLocation W20790731621 @default.
- W2079073162 hasLocation W20790731622 @default.
- W2079073162 hasOpenAccess W2079073162 @default.
- W2079073162 hasPrimaryLocation W20790731621 @default.
- W2079073162 hasRelatedWork W133136368 @default.
- W2079073162 hasRelatedWork W1998567012 @default.
- W2079073162 hasRelatedWork W2011134983 @default.
- W2079073162 hasRelatedWork W2074354560 @default.
- W2079073162 hasRelatedWork W2076869135 @default.
- W2079073162 hasRelatedWork W2079073162 @default.
- W2079073162 hasRelatedWork W2402552335 @default.
- W2079073162 hasRelatedWork W2416251336 @default.
- W2079073162 hasRelatedWork W287767609 @default.
- W2079073162 hasRelatedWork W2921289179 @default.
- W2079073162 hasVolume "23" @default.
- W2079073162 isParatext "false" @default.
- W2079073162 isRetracted "false" @default.
- W2079073162 magId "2079073162" @default.
- W2079073162 workType "article" @default.