Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079073506> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2079073506 endingPage "66" @default.
- W2079073506 startingPage "65" @default.
- W2079073506 abstract "Abstract Objective: Pulmonary transplantation has become the preferred treatment for end-stage lung disease, but application of the procedure is limited because of a paucity of donors. One way to solve donor limitations is to use animal organs as a donor source or xenotransplantation. The current barrier to pulmonary xenotransplantation is the rapid failure of the pulmonary xenograft. Although antibodies are known to play a role in heart and kidney xenograft rejection, their involvement in lung dysfunction is less defined. This project was designed to define the role of antibodies in pulmonary graft rejection in a pig-to-baboon model. Methods: Orthotopic transgenic swine left lung transplants were performed in baboons depleted of antibodies by one of three techniques before transplantation: (1) ex vivo swine kidney perfusion, (2) total immunoglobulin-depleting column perfusion, and (3) ex vivo swine lung perfusion. Results were compared with those of transgenic swine lung transplants in unmodified baboons. Results: All three techniques of antibody removal resulted in depletion of xenoreactive antibodies. Only pretransplantation lung perfusion improved pulmonary xenograft function compared with lung transplantation in unmodified baboons. Conclusions: The pathogenesis of pulmonary injury in a swine-to-primate transplant model is different from that in renal and cardiac xenografts. Depletion of antibodies alone does not have a beneficial effect and may actually be detrimental. (J Thorac Cardiovasc Surg 2000;120:29-38)" @default.
- W2079073506 created "2016-06-24" @default.
- W2079073506 creator A5001363219 @default.
- W2079073506 creator A5001576573 @default.
- W2079073506 creator A5005204277 @default.
- W2079073506 creator A5008561172 @default.
- W2079073506 creator A5008750595 @default.
- W2079073506 creator A5011399299 @default.
- W2079073506 creator A5024353817 @default.
- W2079073506 creator A5025854985 @default.
- W2079073506 creator A5027563261 @default.
- W2079073506 creator A5050670539 @default.
- W2079073506 creator A5054373491 @default.
- W2079073506 creator A5068009045 @default.
- W2079073506 creator A5080088288 @default.
- W2079073506 date "1999-01-01" @default.
- W2079073506 modified "2023-09-27" @default.
- W2079073506 title "The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants" @default.
- W2079073506 doi "https://doi.org/10.1016/s1053-2498(99)80133-8" @default.
- W2079073506 hasPublicationYear "1999" @default.
- W2079073506 type Work @default.
- W2079073506 sameAs 2079073506 @default.
- W2079073506 citedByCount "0" @default.
- W2079073506 crossrefType "journal-article" @default.
- W2079073506 hasAuthorship W2079073506A5001363219 @default.
- W2079073506 hasAuthorship W2079073506A5001576573 @default.
- W2079073506 hasAuthorship W2079073506A5005204277 @default.
- W2079073506 hasAuthorship W2079073506A5008561172 @default.
- W2079073506 hasAuthorship W2079073506A5008750595 @default.
- W2079073506 hasAuthorship W2079073506A5011399299 @default.
- W2079073506 hasAuthorship W2079073506A5024353817 @default.
- W2079073506 hasAuthorship W2079073506A5025854985 @default.
- W2079073506 hasAuthorship W2079073506A5027563261 @default.
- W2079073506 hasAuthorship W2079073506A5050670539 @default.
- W2079073506 hasAuthorship W2079073506A5054373491 @default.
- W2079073506 hasAuthorship W2079073506A5068009045 @default.
- W2079073506 hasAuthorship W2079073506A5080088288 @default.
- W2079073506 hasConcept C126322002 @default.
- W2079073506 hasConcept C159654299 @default.
- W2079073506 hasConcept C177713679 @default.
- W2079073506 hasConcept C203014093 @default.
- W2079073506 hasConcept C2779594886 @default.
- W2079073506 hasConcept C71924100 @default.
- W2079073506 hasConceptScore W2079073506C126322002 @default.
- W2079073506 hasConceptScore W2079073506C159654299 @default.
- W2079073506 hasConceptScore W2079073506C177713679 @default.
- W2079073506 hasConceptScore W2079073506C203014093 @default.
- W2079073506 hasConceptScore W2079073506C2779594886 @default.
- W2079073506 hasConceptScore W2079073506C71924100 @default.
- W2079073506 hasIssue "1" @default.
- W2079073506 hasLocation W20790735061 @default.
- W2079073506 hasOpenAccess W2079073506 @default.
- W2079073506 hasPrimaryLocation W20790735061 @default.
- W2079073506 hasRelatedWork W1981847016 @default.
- W2079073506 hasRelatedWork W2050798911 @default.
- W2079073506 hasRelatedWork W2052556732 @default.
- W2079073506 hasRelatedWork W2080932583 @default.
- W2079073506 hasRelatedWork W2081169667 @default.
- W2079073506 hasRelatedWork W2088370636 @default.
- W2079073506 hasRelatedWork W2150073318 @default.
- W2079073506 hasRelatedWork W2915941616 @default.
- W2079073506 hasRelatedWork W32997870 @default.
- W2079073506 hasRelatedWork W4252371801 @default.
- W2079073506 hasVolume "18" @default.
- W2079073506 isParatext "false" @default.
- W2079073506 isRetracted "false" @default.
- W2079073506 magId "2079073506" @default.
- W2079073506 workType "article" @default.