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- W2079076735 abstract "Serial serum samples and pretreatment and post-treatment liver tissue from patients with chronic hepatitis C virus (HCV) infection were tested for HCV RNA by reverse-transcription polymerase chain reaction and branched DNA signal amplification assays. At the end of treatment with interferon-α (IFNα), 4 of 5 patients showing no biochemical response (in alanine aminotransferase activity), 4 of 5 with transient responses, and 1 of 5 showing complete and sustained responses had HCV RNA detectable in serum. The corresponding numbers for liver tissue were 5, 5, and 0 (of 4). However, all 5 complete responders had virological relapses wdthin 6 months. Biochemical response may not reflect virological profile during IFNα treatment of HCV." @default.
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- W2079076735 date "1994-06-01" @default.
- W2079076735 modified "2023-09-23" @default.
- W2079076735 title "Serum ALT: Tarnished gold standard for interferon response in hepatitis C virus infection" @default.
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- W2079076735 doi "https://doi.org/10.1002/hep.1840190632" @default.
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