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• W2079079425 startingPage "e179" @default.
• W2079079425 abstract "Recent studies have shown that multiple internal models are acquired in the cerebellum and that these can be switched under a given context of behavior. It has been proposed that long-term depression (LTD) of parallel fiber (PF)–Purkinje cell (PC) synapses forms the cellular basis of cerebellar learning, and that the presynaptically synthesized messenger nitric oxide (NO) is a crucial “gatekeeper” for LTD. Because NO diffuses freely to neighboring synapses, this volume learning is not input-specific and brings into question the biological significance of LTD as the basic mechanism for efficient supervised learning. To better characterize the role of NO in cerebellar learning, we simulated the sequence of electrophysiological and biochemical events in PF–PC LTD by combining established simulation models of the electrophysiology, calcium dynamics, and signaling pathways of the PC. The results demonstrate that the local NO concentration is critical for induction of LTD and for its input specificity. Pre- and postsynaptic coincident firing is not sufficient for a PF–PC synapse to undergo LTD, and LTD is induced only when a sufficient amount of NO is provided by activation of the surrounding PFs. On the other hand, above-adequate levels of activity in nearby PFs cause accumulation of NO, which also allows LTD in neighboring synapses that were not directly stimulated, ruining input specificity. These findings lead us to propose the hypothesis that NO represents the relevance of a given context and enables context-dependent selection of internal models to be updated. We also predict sparse PF activity in vivo because, otherwise, input specificity would be lost." @default.
• W2079079425 created "2016-06-24" @default.
• W2079079425 creator A5004840638 @default.
• W2079079425 creator A5010377548 @default.
• W2079079425 creator A5028840283 @default.
• W2079079425 creator A5057900175 @default.
• W2079079425 date "2007-01-12" @default.
• W2079079425 modified "2023-10-18" @default.
• W2079079425 title "Nitric Oxide Regulates Input Specificity of Long-Term Depression and Context Dependence of Cerebellar Learning" @default.
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• W2079079425 doi "https://doi.org/10.1371/journal.pcbi.0020179" @default.
• W2079079425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1769409" @default.
• W2079079425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17222054" @default.
• W2079079425 hasPublicationYear "2007" @default.
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