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• W2079080506 abstract "The present study investigated whether thrombin, a potent microglial activator, can induce reactive oxygen species (ROS) generation through activation of microglial NADPH oxidase and if this may contribute to oxidative damage and consequent neurodegeneration. Seven days after intrahippocampal injection of thrombin, Nissl staining and immunohistochemistry using the neuronal-specific nuclear protein NeuN revealed a significant loss in hippocampal CA1 neurons. In parallel, thrombin-activated microglia, assessed by OX-42 and OX-6 immunohistochemistry, and ROS production, assessed by hydroethidine histochemistry, were observed in the hippocampal CA1 area in which degeneration of hippocampal neurons occurred. Reverse transcription-PCR at various time points after thrombin administration demonstrated an early and transient expression of inducible nitric oxide synthase (iNOS) and several proinflammatory cytokines. Western blot analysis and double-label immunohistochemistry showed an increase in the expression of and the localization of iNOS within microglia. Additional studies demonstrated that thrombin induced the upregulation of membrane (gp91(phox)) and cytosolic (p47(phox) and p67(phox)) components, translocation of cytosolic proteins (p47(phox), p67(phox), and Rac1) to the membrane, and p67(phox) expression of the NADPH oxidase in microglia in the hippocampus in vivo, indicating the activation of NADPH oxidase. The thrombin-induced oxidation of proteins and loss of hippocampal CA1 neurons were partially inhibited by an NADPH oxidase inhibitor and by an antioxidant. To our knowledge, the present study is the first to demonstrate that thrombin-induced neurotoxicity in the hippocampus in vivo is caused by microglial NADPH oxidase-mediated oxidative stress. This suggests that thrombin inhibition or enhancing antioxidants may be beneficial for the treatment of neurodegenerative diseases, such as Alzheimer's disease, that are associated with microglial-derived oxidative damage." @default.
• W2079080506 created "2016-06-24" @default.
• W2079080506 creator A5005061114 @default.
• W2079080506 creator A5040109906 @default.
• W2079080506 creator A5041169735 @default.
• W2079080506 creator A5060641907 @default.
• W2079080506 date "2005-04-20" @default.
• W2079080506 modified "2023-09-26" @default.
• W2079080506 title "Thrombin-Induced Oxidative Stress Contributes to the Death of Hippocampal Neurons<i>In Vivo</i>: Role of Microglial NADPH Oxidase" @default.
• W2079080506 cites W1489032270 @default.
• W2079080506 cites W1493941654 @default.
• W2079080506 cites W1495997476 @default.
• W2079080506 cites W1500418512 @default.
• W2079080506 cites W1526678238 @default.
• W2079080506 cites W1549264432 @default.
• W2079080506 cites W1576211545 @default.
• W2079080506 cites W1579589376 @default.
• W2079080506 cites W1586099293 @default.
• W2079080506 cites W1968443425 @default.
• W2079080506 cites W1971701992 @default.
• W2079080506 cites W1973797728 @default.
• W2079080506 cites W1976625832 @default.
• W2079080506 cites W1977280291 @default.
• W2079080506 cites W1980132212 @default.
• W2079080506 cites W1982562954 @default.
• W2079080506 cites W1988210470 @default.
• W2079080506 cites W1988396863 @default.
• W2079080506 cites W1995674856 @default.
• W2079080506 cites W1999190313 @default.
• W2079080506 cites W2000636649 @default.
• W2079080506 cites W2001531946 @default.
• W2079080506 cites W2006331624 @default.
• W2079080506 cites W2010312001 @default.
• W2079080506 cites W2011481598 @default.
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• W2079080506 cites W2025695179 @default.
• W2079080506 cites W2027189256 @default.
• W2079080506 cites W2034354351 @default.
• W2079080506 cites W2039222951 @default.
• W2079080506 cites W2042691848 @default.
• W2079080506 cites W2043155515 @default.
• W2079080506 cites W2046874923 @default.
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• W2079080506 cites W2049262684 @default.
• W2079080506 cites W2052119252 @default.
• W2079080506 cites W2052411910 @default.
• W2079080506 cites W2060694569 @default.
• W2079080506 cites W2065062958 @default.
• W2079080506 cites W2066888066 @default.
• W2079080506 cites W206963456 @default.
• W2079080506 cites W2071793324 @default.
• W2079080506 cites W2072569792 @default.
• W2079080506 cites W2081312692 @default.
• W2079080506 cites W2081475948 @default.
• W2079080506 cites W2082294005 @default.
• W2079080506 cites W2085981166 @default.
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• W2079080506 cites W2096901938 @default.
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• W2079080506 cites W2103711259 @default.
• W2079080506 cites W2116784956 @default.
• W2079080506 cites W2120334927 @default.
• W2079080506 cites W2123548739 @default.
• W2079080506 cites W2127460445 @default.
• W2079080506 cites W2130440272 @default.
• W2079080506 cites W2130753450 @default.
• W2079080506 cites W2138760592 @default.
• W2079080506 cites W2140616438 @default.
• W2079080506 cites W2147313422 @default.
• W2079080506 cites W2149954869 @default.
• W2079080506 cites W2153177211 @default.
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• W2079080506 cites W2159027833 @default.
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• W2079080506 doi "https://doi.org/10.1523/jneurosci.4306-04.2005" @default.
• W2079080506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6724962" @default.
• W2079080506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15843610" @default.
• W2079080506 hasPublicationYear "2005" @default.
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