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• W2079083668 abstract "Both S-(-)- and R-(+)-nicotine enantiomers are inhibitors of histamine N tau-methylation activity in guinea-pig pulmonary alveolar macrophage cultures, exhibiting IC50 values of 7 and 8 microM, respectively. S-(-)-Nicotine is not biotransformed under the conditions of the experiment, however, R-(+)-nicotine undergoes significant N-methylation to produce N-methylnicotinium ion. S-(-)-Nicotine appears to inhibit the N-methylation of its optical antipode by the alveolar nicotine N-methyltransferase. The results indicate that a contributing factor in the toxicology of cigarette smoke inhalation may be due to the inhibition of pulmonary metabolism of histamine by nicotine." @default.
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• W2079083668 date "1988-10-01" @default.
• W2079083668 modified "2023-09-25" @default.
• W2079083668 title "Inhibition of histamine N-methyltransferase activity in guinea-pig pulmonary alveolar macrophages by nicotine" @default.
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• W2079083668 doi "https://doi.org/10.1111/j.2042-7158.1988.tb07004.x" @default.
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