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- W2079084885 abstract "In the present investigation, the antinociceptive, motor blocking and neurotoxic effects of intrathecal and epidural somatostatin (SST) were assessed in rats implanted with lumbar intrathecal and epidural catheters. The doses studied were 5, 7.5, 10, 12.5 and 15 μg intrathecally and 100, 250, 400 and 500 μg epidurally. It appears that if the intrathecal doses of SST are kept below 15 μg and the epidural doses below 250 μg, the prolonged tail-flick latency can be separated from the transient motor blockade. The antinociception appears not to be attributable to neurotoxicity by the histological evidence available." @default.
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- W2079084885 date "1990-12-01" @default.
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- W2079084885 title "Intrathecal and epidural somatostatin in rats: can antinociception, motor effects and neurotoxicity be separated?" @default.
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- W2079084885 doi "https://doi.org/10.1016/0304-3959(90)90033-a" @default.
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