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- W2079084886 abstract "A PUFA-deficient diet causes deficiency symptoms and alters the fatty acid pattern in liver microsomal lipids. However, CCl4 lethality and sleeping time remain unchanged while the hepatic level of cytochrome P450 is only slightly lowered by the dietary regimen. In accordance, the amplitude of double bond shifting in microsomal lipids is far from being depressed in animals deprived of the peroxidative substrate. In fact, the experimental treatment does not impair intestinal absorption, liver uptake and metabolism of CCl4 given orally. Finally, both in vitro and in vivo peroxidative challenge of arachidonic acid content in hepatic microsomes causes comparable alterations of this parameter, whatever the initial fatty acid pattern following the dietary regimen. These findings provide evidence excluding an influence of the fatty acid composition of the diet on the severity of damages due to halogen-alkane exposure." @default.
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- W2079084886 date "1982-01-01" @default.
- W2079084886 modified "2023-09-26" @default.
- W2079084886 title "Mechanism of Protection against Carbon Tetrachloride Toxicity Ii. Lethality in Rats Fed a Polyunsaturated Fatty Acid Deficient Diet" @default.
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- W2079084886 doi "https://doi.org/10.3109/01480548209017774" @default.
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