FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079085491> ?p ?o ?g. }

• W2079085491 endingPage "522" @default.
• W2079085491 startingPage "522" @default.
• W2079085491 abstract "<h3>Summary</h3> <h3>Background</h3> The key role of inflammation in the progression of COVID-19 was evident right from the beginning of the pandemic. Consequently, many authors studied the onset and evolution of the cytokine storm. In contrast, other inflammatory mediators such as oxylipins have received almost no attention. <h3>Methods</h3> We conducted a monocentric observational and retrospective study (IMPRE-COVID-19) with patients (aged ≥ 18 years) admitted to Pisa University Hospital with COVID-19 related pneumonia. SARS-CoV-2 infection was confirmed by polymerase chain reaction in a nasopharyngeal swab, while pneumonia was demonstrated by CT scan. Oxylipin plasma levels were analysed in a convenient sample of 52 patients randomly selected from those that had a complete set of cytokine values evaluated for clinical purposes. In 12 cases, plasma samples collected on different days were available at the BMS Multispecialistic Biobank of Pisa University Hospital and were analysed to understand the evolution of the oxylipin levels during hospitalization. The two datasets that included oxylipin and cytokine values were analysed by principal component analysis (PCA), computation of Fisher’s canonical variable, and a multivariate receiver operating characteristic (ROC) curve. <h3>Findings</h3> Between March and April 2020, 52 patients were enrolled of which 28 were hospitalised in COVID-19 wards, 20 in ICUs, and 4 who were initially hospitalised in the wards and who were then transferred to the ICUs due to deteriorating health conditions. Plasma samples collected on different days were available from 7 patients in the wards, 1 from an ICU, and 4 from patients who were hospitalised in both. The mean age of participants was 61 years (SD 16), 11 were females (21%), and 41 were males (79%), without significant differences between groups in terms of age and gender. PCA of oxylipin data led to a clear differentiation of samples collected in COVID-19 wards and ICUs. This differentiation had not been obtained with cytokine data. In addition, borderline samples were from patients hospitalised in COVID-19 wards that were about to be transferred to the ICUs, thus suggesting that differentiation is not a consequence of a different treatment, but somehow related to a diverse evolution of the pathology. Computation of Fisher’s canonical variable identified the original input variables that were the most effective in discriminating between the two classes. The combination of the two datasets did not improve the discrimination, thus suggesting that oxylipins are more informative than cytokines for this purpose. A multivariate class model built using the four lowest-order principal components as the input variables, and COVID-19 ward samples as the target class, produced a ROC curve with a resulting area under the curve (AUC) equal to 0·92 – which is much higher than most AUC outcomes obtained for individual oxylipins. <h3>Interpretation</h3> After analysing the metabolic pathways of the most informative oxylipins, we speculate that more severe COVID-19 is associated with a selective deficiency of pro-resolving oxylipins leading to ineffective resolutive mechanisms of inflammation, likely worsened by endothelial damage. We believe that our oxylipin data suggest the possibility to predict the evolution of COVID-19 in individual patients at an early stage. <h3>Funding</h3> Institutional funds from the University of Pisa supported the study." @default.
• W2079085491 created "2016-06-24" @default.
• W2079085491 creator A5024477618 @default.
• W2079085491 date "1974-03-16" @default.
• W2079085491 modified "2023-09-27" @default.
• W2079085491 title "Western and Witch Doctors: Two Cultures" @default.
• W2079085491 doi "https://doi.org/10.1136/bmj.1.5906.522-b" @default.
• W2079085491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1633487" @default.
• W2079085491 hasPublicationYear "1974" @default.
• W2079085491 type Work @default.
• W2079085491 sameAs 2079085491 @default.
• W2079085491 citedByCount "0" @default.
• W2079085491 crossrefType "journal-article" @default.
• W2079085491 hasAuthorship W2079085491A5024477618 @default.
• W2079085491 hasBestOaLocation W20790854912 @default.
• W2079085491 hasConcept C126322002 @default.
• W2079085491 hasConcept C167135981 @default.
• W2079085491 hasConcept C177713679 @default.
• W2079085491 hasConcept C187212893 @default.
• W2079085491 hasConcept C194828623 @default.
• W2079085491 hasConcept C23131810 @default.
• W2079085491 hasConcept C2777914695 @default.
• W2079085491 hasConcept C2779134260 @default.
• W2079085491 hasConcept C3008058167 @default.
• W2079085491 hasConcept C524204448 @default.
• W2079085491 hasConcept C58471807 @default.
• W2079085491 hasConcept C71924100 @default.
• W2079085491 hasConcept C77350462 @default.
• W2079085491 hasConceptScore W2079085491C126322002 @default.
• W2079085491 hasConceptScore W2079085491C167135981 @default.
• W2079085491 hasConceptScore W2079085491C177713679 @default.
• W2079085491 hasConceptScore W2079085491C187212893 @default.
• W2079085491 hasConceptScore W2079085491C194828623 @default.
• W2079085491 hasConceptScore W2079085491C23131810 @default.
• W2079085491 hasConceptScore W2079085491C2777914695 @default.
• W2079085491 hasConceptScore W2079085491C2779134260 @default.
• W2079085491 hasConceptScore W2079085491C3008058167 @default.
• W2079085491 hasConceptScore W2079085491C524204448 @default.
• W2079085491 hasConceptScore W2079085491C58471807 @default.
• W2079085491 hasConceptScore W2079085491C71924100 @default.
• W2079085491 hasConceptScore W2079085491C77350462 @default.
• W2079085491 hasIssue "5906" @default.
• W2079085491 hasLocation W20790854911 @default.
• W2079085491 hasLocation W20790854912 @default.
• W2079085491 hasOpenAccess W2079085491 @default.
• W2079085491 hasPrimaryLocation W20790854911 @default.
• W2079085491 hasRelatedWork W1975046232 @default.
• W2079085491 hasRelatedWork W2008609309 @default.
• W2079085491 hasRelatedWork W2098128590 @default.
• W2079085491 hasRelatedWork W2166247085 @default.
• W2079085491 hasRelatedWork W2313076522 @default.
• W2079085491 hasRelatedWork W2329095872 @default.
• W2079085491 hasRelatedWork W3040911544 @default.
• W2079085491 hasRelatedWork W3071226507 @default.
• W2079085491 hasRelatedWork W3080202218 @default.
• W2079085491 hasRelatedWork W4220750556 @default.
• W2079085491 hasVolume "1" @default.
• W2079085491 isParatext "false" @default.
• W2079085491 isRetracted "false" @default.
• W2079085491 magId "2079085491" @default.
• W2079085491 workType "article" @default.