Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079086000> ?p ?o ?g. }
- W2079086000 endingPage "319" @default.
- W2079086000 startingPage "310" @default.
- W2079086000 abstract "The effects of modulators of GABA-A receptors on neuronal network activity were studied in the neonatal (postnatal days 0-5) rat hippocampus in vitro. Under control conditions, the physiological pattern of activity of the neonatal hippocampal network was characterized by spontaneous network-driven giant depolarizing potentials (GDPs). The GABA-A receptor agonist isoguvacine (1-2 microM) and the allosteric modulator diazepam (2 microM) induced biphasic responses: initially the frequency of GDPs increased 3 to 4 fold followed by blockade of GDPs and desynchronization of the network activity. The GABA-A receptor antagonists bicuculline (10 microM) and picrotoxin (100 microM) blocked GDPs and induced glutamate (AMPA and NMDA)-receptor-mediated interictal- and ictal-like activities in the hippocampal slices and the intact hippocampus. These data suggest that at early postnatal ages GABA can exert a dual - both excitatory and inhibitory - action on the network activity." @default.
- W2079086000 created "2016-06-24" @default.
- W2079086000 creator A5041824506 @default.
- W2079086000 creator A5048298627 @default.
- W2079086000 creator A5070034473 @default.
- W2079086000 creator A5082071725 @default.
- W2079086000 date "1999-01-01" @default.
- W2079086000 modified "2023-10-12" @default.
- W2079086000 title "Dual Role of GABA in the Neonatal Rat Hippocampus" @default.
- W2079086000 cites W110129881 @default.
- W2079086000 cites W1484279823 @default.
- W2079086000 cites W1487954084 @default.
- W2079086000 cites W1563576581 @default.
- W2079086000 cites W1856380311 @default.
- W2079086000 cites W1964418945 @default.
- W2079086000 cites W1967475203 @default.
- W2079086000 cites W1973108213 @default.
- W2079086000 cites W1976416612 @default.
- W2079086000 cites W1992665201 @default.
- W2079086000 cites W1992792117 @default.
- W2079086000 cites W2010744854 @default.
- W2079086000 cites W2015262462 @default.
- W2079086000 cites W2018908670 @default.
- W2079086000 cites W2024328209 @default.
- W2079086000 cites W2025388015 @default.
- W2079086000 cites W2025559018 @default.
- W2079086000 cites W2035289053 @default.
- W2079086000 cites W2042888311 @default.
- W2079086000 cites W2050651528 @default.
- W2079086000 cites W2060589548 @default.
- W2079086000 cites W2076969814 @default.
- W2079086000 cites W2084866099 @default.
- W2079086000 cites W2088115551 @default.
- W2079086000 cites W2091040471 @default.
- W2079086000 cites W2093381661 @default.
- W2079086000 cites W2105585258 @default.
- W2079086000 cites W2106452927 @default.
- W2079086000 cites W2117770051 @default.
- W2079086000 cites W2123333981 @default.
- W2079086000 cites W2126578880 @default.
- W2079086000 cites W2128273650 @default.
- W2079086000 cites W2137730912 @default.
- W2079086000 cites W2146828561 @default.
- W2079086000 cites W2147827183 @default.
- W2079086000 cites W2160205444 @default.
- W2079086000 cites W2160584179 @default.
- W2079086000 cites W2160607236 @default.
- W2079086000 cites W2414806773 @default.
- W2079086000 doi "https://doi.org/10.1159/000017380" @default.
- W2079086000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10575254" @default.
- W2079086000 hasPublicationYear "1999" @default.
- W2079086000 type Work @default.
- W2079086000 sameAs 2079086000 @default.
- W2079086000 citedByCount "105" @default.
- W2079086000 countsByYear W20790860002012 @default.
- W2079086000 countsByYear W20790860002013 @default.
- W2079086000 countsByYear W20790860002014 @default.
- W2079086000 countsByYear W20790860002015 @default.
- W2079086000 countsByYear W20790860002016 @default.
- W2079086000 countsByYear W20790860002017 @default.
- W2079086000 countsByYear W20790860002018 @default.
- W2079086000 countsByYear W20790860002019 @default.
- W2079086000 countsByYear W20790860002020 @default.
- W2079086000 countsByYear W20790860002021 @default.
- W2079086000 countsByYear W20790860002022 @default.
- W2079086000 countsByYear W20790860002023 @default.
- W2079086000 crossrefType "journal-article" @default.
- W2079086000 hasAuthorship W2079086000A5041824506 @default.
- W2079086000 hasAuthorship W2079086000A5048298627 @default.
- W2079086000 hasAuthorship W2079086000A5070034473 @default.
- W2079086000 hasAuthorship W2079086000A5082071725 @default.
- W2079086000 hasConcept C112592302 @default.
- W2079086000 hasConcept C126322002 @default.
- W2079086000 hasConcept C148762608 @default.
- W2079086000 hasConcept C160268369 @default.
- W2079086000 hasConcept C168258287 @default.
- W2079086000 hasConcept C169760540 @default.
- W2079086000 hasConcept C170493617 @default.
- W2079086000 hasConcept C17077164 @default.
- W2079086000 hasConcept C185592680 @default.
- W2079086000 hasConcept C2778938600 @default.
- W2079086000 hasConcept C2779324764 @default.
- W2079086000 hasConcept C2780763569 @default.
- W2079086000 hasConcept C2781161787 @default.
- W2079086000 hasConcept C61174792 @default.
- W2079086000 hasConcept C67018056 @default.
- W2079086000 hasConcept C71924100 @default.
- W2079086000 hasConcept C79636183 @default.
- W2079086000 hasConcept C86803240 @default.
- W2079086000 hasConceptScore W2079086000C112592302 @default.
- W2079086000 hasConceptScore W2079086000C126322002 @default.
- W2079086000 hasConceptScore W2079086000C148762608 @default.
- W2079086000 hasConceptScore W2079086000C160268369 @default.
- W2079086000 hasConceptScore W2079086000C168258287 @default.
- W2079086000 hasConceptScore W2079086000C169760540 @default.
- W2079086000 hasConceptScore W2079086000C170493617 @default.
- W2079086000 hasConceptScore W2079086000C17077164 @default.
- W2079086000 hasConceptScore W2079086000C185592680 @default.